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Modeling of stretch-activated sarcolemmal channels in smooth muscle cells
Department of Medical Information Technology, RWTH Aachen.
Linköping University, Department of Management and Engineering, Mechanics. Linköping University, The Institute of Technology.
Department of Medical Information Technology, RWTH Aachen.
2009 (English)In: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: Vol. 25/4 Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics / [ed] Dössel, Olaf; Schlegel, Wolfgang C., Springer Berlin/Heidelberg, 2009, 740-743 p.Conference paper, Published paper (Refereed)
Abstract [en]

This paper concerns the electrochemical modeling of vascular smooth muscle cells. The aim is to describe the influence of cell stretch on the intracelluar calcium concentration. A state-of-the-art cell model is extended by a stretch-activated sarcolemmal channel. Two representations for this channel are developed which describe several electrical and chemical cell membrane properties. The unknown parameters of the new channels are identified by comparing the simulation results with experimental data. The extended cell model shows a typical transient behavior for stretch stimulation. As the most important characteristic it reflects the generation of action potentials induced by cell elongation.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2009. 740-743 p.
Series
IFMBE Proceedings, ISSN 1680-0737 ; 25/4
Keyword [en]
vascular smooth muscle cell, electrochemical cell model, cell stretch, intracellular calcium concentration, action potential
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-60914DOI: 10.1007/978-3-642-03882-2-197ISBN: 9783642038815 (print)ISBN: 9783642038822 (electronic)OAI: oai:DiVA.org:liu-60914DiVA: diva2:359727
Conference
World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany
Available from: 2010-10-29 Created: 2010-10-29 Last updated: 2017-02-09Bibliographically approved

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Stålhand, Jonas

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
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  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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  • asciidoc
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