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Modeling of stretch-activated sarcolemmal channels in smooth muscle cells
Department of Medical Information Technology, RWTH Aachen.
Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
Department of Medical Information Technology, RWTH Aachen.
2009 (English)In: IFMBE Proceedings / [ed] Dössel, Olaf; Schlegel, Wolfgang C., 2009, 740-743 p.Conference paper (Refereed)
Abstract [en]

This paper concerns the electrochemical modeling of vascular smooth muscle cells. The aim is to describe the influence of cell stretch on the intracelluar calcium concentration. A state-of-the-art cell model is extended by a stretch-activated sarcolemmal channel. Two representations for this channel are developed which describe several electrical and chemical cell membrane properties. The unknown parameters of the new channels are identified by comparing the simulation results with experimental data. The extended cell model shows a typical transient behavior for stretch stimulation. As the most important characteristic it reflects the generation of action potentials induced by cell elongation.

Place, publisher, year, edition, pages
2009. 740-743 p.
, IFMBE Proceedings, ISSN 16800737 ; 25/9
Keyword [en]
vascular smooth muscle cell, electrochemical cell model, cell stretch, intracellular calcium concentration, action potential
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-60914DOI: 10.1007/978-3-642-03882-2-197ISBN: 978-364203881-5OAI: diva2:359727
World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany
Available from: 2010-10-29 Created: 2010-10-29 Last updated: 2010-12-13

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Stålhand, Jonas
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ReferencesLink to record
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