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Effects of simvastatin on carotenoid status in plasma
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Occupational and Environmental Medicine Centre.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
2010 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Purpose: Carotenoids are potent antioxidants and immunomodulators mainly transported in the low density lipoprotein (LDL) fraction. It is well known that low plasma carotenoids are associated with cardiovascular disease incidence. We investigated whether simvastatin altered the carotenoid status in plasma.

Methods: A randomized double-blind study design was used. Eighty volunteers with mild to moderate hypercholesterolemia received either simvastatin 40 mg or placebo for 6 weeks. Lipids, inflammatory markers, oxygenated carotenoids (lutein, zeaxanthin, beta-cryptoxanthin) and hydrocarbon carotenoids (alphacarotene, beta-carotene and lycopene) were measured in plasma.

Results: After simvastatin therapy, total cholesterol, LDL, apolipoprotein B (apo B), oxidized LDL and C-reactive protein were significantly reduced. Simvastatin therapy also resulted in significantly reduced plasma levels of all crude major carotenoids. However, after adjustment for total cholesterol, LDL or apo B, all carotenoids except beta-cryptoxanthin increased during statin therapy (see Table). The carotenoids were inversely correlated with inflammatory markers but these correlations were abolished during simvastatin therapy.

Conclusions: The increase in lipid-adjusted levels of carotenoids during simvastatin therapy suggest that lipoproteins had become enriched with carotenoids. The data highlight the risk to misinterpret the carotenoid status in individuals with statin therapy if relying on absolute plasma levels.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2010. Vol. 31, no Suppl. 675, P3984- p.
Series
European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645
Keyword [en]
Statin; Carotenoid; Lipid; Lipoprotein; Inflammation
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-60934DOI: 10.1093/eurheartj/ehq289ISI: 000281531904328OAI: oai:DiVA.org:liu-60934DiVA: diva2:359954
Conference
The ESC Congress 2010, Stockholm, Sweden, 28 augusti-1 september
Note

Presented at the ESC Congress 2010, Stockholm, Sweden, 28 augusti-1 september 2010.

Available from: 2010-11-01 Created: 2010-11-01 Last updated: 2017-02-21Bibliographically approved

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Rydén, MireilleLeanderson, PerJonasson, Lena

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CardiologyFaculty of Health SciencesOccupational and Environmental MedicineOccupational and Environmental Medicine CentreDepartment of Cardiology
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