liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Deficiency of Activating Fc gamma-Receptors Reduces Hepatic Clearance and Deposition of IC and Increases CIC Levels in Mercury-Induced Autoimmunity
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.ORCID iD: 0000-0002-0153-9249
Rikshospital University Hospital, Oslo.
University of Oslo.
Show others and affiliations
2010 (English)In: PLOS ONE, ISSN 1932-6203, Vol. 5, no 10Article in journal (Refereed) Published
Abstract [en]

Background: Inorganic mercury (Hg) induces a T-cell dependent, systemic autoimmune condition (HgIA) where activating Fc gamma-receptors (Fc gamma Rs) are important for the induction. In this study we examined the influence of activating Fc gamma Rs on circulating levels and organ localization of immune complexes (IC) in HgIA. Methods and Principal Findings: Mercury treated BALB/c wt mice showed a significant but modest increase of circulating IC (CIC) from day 12 until day 18 and day 35 for IgG2a- and IgG1- CIC, respectively. Mercury-treated mice lacking the transmembrane gamma-chain of activating Fc gamma Rs (FcR gamma(-/-)) had significantly higher CIC levels of both IgG1-CIC and IgG2a-CIC than wt mice during the treatment course. The hepatic uptake of preformed CIC was significantly more efficient in wt mice compared to Fc gamma R-/- mice, but also development of extrahepatic tissue IC deposits was delayed in FcR gamma(-/-) mice. After 35 days of Hg treatment the proportion of immune deposits, as well as the amounts was significantly reduced in vessel FcR gamma(-/-) mice compared to wt mice. Conclusions: We conclude that mice lacking functional activating Fc gamma Rs respond to Hg with increased levels and altered quality of CIC compared with wt mice. Lack of functional activating Fc gamma Rs delayed the elimination of CIC, but also significantly reduced extrahepatic tissue localization of CIC.

Place, publisher, year, edition, pages
Public Library of Science (PLoS) , 2010. Vol. 5, no 10
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-61176DOI: 10.1371/journal.pone.0013413ISI: 000283043700013OAI: oai:DiVA.org:liu-61176DiVA: diva2:361042
Note
Original Publication: Klara Martinsson, Thomas Skogh, Seyed Ali Mousavi, Trond Berg, Jan-Ingvar Jönsson and Per Hultman, Deficiency of Activating Fc gamma-Receptors Reduces Hepatic Clearance and Deposition of IC and Increases CIC Levels in Mercury-Induced Autoimmunity, 2010, PLOS ONE, (5), 10. http://dx.doi.org/10.1371/journal.pone.0013413 Licensee: Public Library of Science (PLoS) http://www.plos.org/ Available from: 2010-11-08 Created: 2010-11-05 Last updated: 2015-08-31

Open Access in DiVA

fulltext(3859 kB)369 downloads
File information
File name FULLTEXT01.pdfFile size 3859 kBChecksum SHA-512
ce8c5674c03b8eceaa077162df6339e6e77041cd02c4642631cfca696bb2553ff0b3ef92fb62beb927c650c29a865d5327ba15f5968d3570075bc38e33f591e4
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Martinsson, KlaraSkogh, ThomasJönsson, Jan-IngvarHultman, Per

Search in DiVA

By author/editor
Martinsson, KlaraSkogh, ThomasJönsson, Jan-IngvarHultman, Per
By organisation
Department of Clinical and Experimental MedicineFaculty of Health SciencesRheumatology Department of Rheumatology in ÖstergötlandExperimental Hematology Molecular and Immunological Pathology Department of Clinical Pathology and Clinical Genetics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 369 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 191 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf