liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Depressive symptoms and outcomes in patients with heart failure: data from the COACH study.
Show others and affiliations
2009 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 11, no 12, 1202-7 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: To study the prognostic value of depressive symptoms on heart failure (HF) readmission and mortality, in a large and clinically relevant population of hospitalized HF patients adjusted for disease severity by B-type natriuretic peptide (BNP) level. METHODS AND RESULTS: We studied 958 patients enrolled after hospitalization for HF; 37% female; mean age 71 +/- 11 years; New York Heart Association class II (51%) or III/IV (49%). Left ventricular ejection fraction: 33% +/- 14%, and median BNP level: 454 pg/mL (75% CI, 195-876 pg/mL). In total, 377 patients (39%) had depressive symptoms [Centre for Epidemiological Studies Depression Scale (CES-D) score >or=16] and 200 (21%) had severe depressive symptoms (score >or=24). During 18 months of follow-up, 386 (40%) patients reached the primary endpoint of death or readmission for HF. In multivariate analyses, CES-D was significantly associated with the primary endpoint [hazard ratio (HR) 1.13, P = 0.02], and also with both individual components of the primary endpoint [HF readmission (HR 1.165, P = 0.02) and mortality (HR 1.169, P = 0.02)]. Patients with severe depressive symptoms had a >40% higher risk for HF readmission or death. CONCLUSION: In patients with HF, depression is independently associated with poor outcomes. These findings highlight the need for continued exploration of whether improvements in depression lead to better cardiovascular outcomes. The study was registered at clinical trial ( NCT 98675639.

Place, publisher, year, edition, pages
2009. Vol. 11, no 12, 1202-7 p.
URN: urn:nbn:se:liu:diva-62411DOI: 10.1093/eurjhf/hfp155PubMedID: 19926602OAI: diva2:373200
Available from: 2010-11-30 Created: 2010-11-30 Last updated: 2010-11-30

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
European Journal of Heart Failure

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 28 hits
ReferencesLink to record
Permanent link

Direct link