Weight gain by hyperalimentation elevates C-reactive protein levels but does not affect circulating levels of adiponectin or resistin in healthy subjects
2010 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 163, no 6, 879-885 p.Article in journal (Refereed) Published
Objective: Increase of resistin and/or reduction of adiponectin have beenimplicated in the development of insulin resistance followingweight gain. We aimed to study this prospectively in humans.
Design: Prospective and interventional with parallel control group.
Methods: Twelve healthy men and six healthy women (age 26±6.6years) and an age-matched control group were recruited. Subjectsin the intervention group aimed for a bodyweight increase of5–15% by doubling the baseline caloric intake by eatingat least two fast food-based meals a day in combination withadoption of a sedentary lifestyle for 4 weeks.
Results: Bodyweight increased from 67.6±9.1 to 74.0±11kg, P<0.001, by the intervention. Insulin levels increased(before: 27.4±12 pmol/l, after: 53.0±22 pmol/l,P=0.004), while plasma levels of adiponectin (before: 5038±3736ng/ml, after: 6739±7949 ng/ml, P=0.18) and resistin (before:21.8±19 ng/ml, after: 14.4±6.8 ng/ml, P=0.074)remained unchanged by the weight gain and were similar as incontrols. On the other hand, leptin levels increased about threefoldfollowing the intervention (before: 5.7±7.4, after: 16±20ng/ml, P=0.008), and also the inflammatory marker C-reactiveprotein (CRP) increased from 0.34±0.44 to 0.71±0.87mg/l, P=0.03, when two outliers >10 mg/l were disregarded.
Conclusions: Hyperalimentation reduces insulin sensitivity when weight gainof 9% was combined with reduction of exercise. However, thelevels of resistin and adiponectin were unaffected by the intervention,while CRP levels increased within this short time period suggestingthat low-grade inflammation can occur early in the process ofdeveloping a metabolic syndrome.
Place, publisher, year, edition, pages
Bristol: BioScientifica , 2010. Vol. 163, no 6, 879-885 p.
National CategoryEndocrinology and Diabetes
IdentifiersURN: urn:nbn:se:liu:diva-62665DOI: 10.1530/EJE-10-0763ISI: 000284098400005OAI: oai:DiVA.org:liu-62665DiVA: diva2:373895
Disclaimer. This is not the definitive version of record of this article. This manuscript has been accepted for publication in European Journal of Endocrinology, but the version presented here has not yet been copy edited, formatted or proofed. Consequently, the journal accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at: Olov Åstrand, Martin Carlsson, Ingela Nilsson, Torbjörn Lindström, Magnus Borga and Fredrik Nyström, Weight gain by hyperalimentation elevates C-reactive protein levels but does not affect circulating levels of adiponectin or resistin in healthy subjects, 2010, European Journal of Endocrinology, (163), 6, 879-885. http://dx.doi.org/10.1530/EJE-10-0763 Copyright: Bio Scientifica http://www.eje-online.org/2010-12-012010-12-012014-10-08Bibliographically approved