liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Sera from Preeclampsia Patients Elicit Symptoms of Human Disease in Mice and Provide a Basis for an in Vitro Predictive Assay
Women and Infants Hospital Rhode Island.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology . Linköping University, Faculty of Health Sciences.
Women and Infants Hospital Rhode Island.
Brown University.
Show others and affiliations
2010 (English)In: AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, Vol. 177, no 5, 2387-2398 p.Article in journal (Refereed) Published
Abstract [en]

Early diagnosis and treatment of preeclampsia would significantly reduce maternal and fetal morbidity and mortality. However, its etiology and prediction have remained elusive. Based on the hypothesis that sera from patients with preeclampsia could function as a "blueprint" of causative factors, we describe a serum-based pregnancy-specific mouse model that closely mirrors the human condition as well as an in vitro predictive assay. We show that a single administration of human preeclampsia serum in pregnant IL-10(-/-) mice induced the full spectrum of preeclampsia-like symptoms, caused hypoxic injury in uteroplacental tissues, and elevated soluble fins-like tyrosine kinase 1 and soluble endoglin, markers thought to be related to the disease. The same serum sample(s) induced a partial preeclampsia phenotype in wild-type mice. Importantly, preeclampsia serum disrupted cross talk between trophoblasts and endothelial cells in an in vitro model of endovascular activity. Disruption of endovascular activity could be documented in serum samples as early as 12 to 14 weeks of gestation from patients who subsequently developed preeclampsia. These results indicate that preeclampsia patient sera can be used to understand the pregnancy-specific disease pathology in mice and can predict the disorder.

Place, publisher, year, edition, pages
American Society for Investigative Pathology (ASIP) , 2010. Vol. 177, no 5, 2387-2398 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-62755DOI: 10.2353/ajpath.2010.100475ISI: 000284182900026OAI: diva2:374198
Available from: 2010-12-03 Created: 2010-12-03 Last updated: 2010-12-03

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Obstetrics and gynecology Faculty of Health Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 17 hits
ReferencesLink to record
Permanent link

Direct link