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The effect of pacing-induced heart rate variation on longitudinal and circumferential regional myocardial function after acute beta-blockade a cardiac ultrasound study
Östergötlands Läns Landsting, Heart Centre.
Linköping University, Department of Medicine and Health Sciences, Clinical Physiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre.
Linköping University, Department of Medicine and Care, Anaesthesiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Intensive Care UHL.
University of Heidelberg.
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2000 (English)In: European Journal of Echocardiography, ISSN 1525-2167, E-ISSN 1532-2114, Vol. 1, no 3, 184-195 p.Article in journal (Refereed) Published
Abstract [en]

Aims: To evaluate the effect of acute beta-blockade in combination with differing heart rates on longitudinal and circumferential regional myocardial function using Doppler myocardial imaging and two-dimensional-echocardiography.

Methods and Results: In seven pigs the following echocardiographic indices were measured at baseline, after beta-blockade both without and with atrial pacing: wall thickening fraction, fractional shortening, myocardial peak systolic velocity, transmyocardial velocity gradient and systolic velocity time integral of the posterolateral wall in short-axis view; mitral valve plane excursion, myocardial peak systolic velocity and systolic velocity time integral of the posterolateral wall in an apical five-chamber view. Peak systolic velocities and velocity gradients decreased significantly following acute beta-blockade but no further decay occurred at high heart rate due to pacing. The velocity time integrals and mitral valve plane excursion showed a tendency to decrease following beta-blockade but only after pacing were they significantly reduced. The wall thickening fraction and fractional shortening showed a significant reduction after beta-blockade but no further decay after pacing.

Conclusions: Changes in systolic velocities and velocity gradients were independent of heart rate reduction under high dosage beta-blockade, whereas wall thickening fraction, mitral valve plane excursion and velocity time integrals changed due to pacing.

Place, publisher, year, edition, pages
2000. Vol. 1, no 3, 184-195 p.
Keyword [en]
doppler myocardial imagingleft ventricular functionbeta-blockadeheart rate variation
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-62976DOI: 10.1053/euje.2000.0030OAI: oai:DiVA.org:liu-62976DiVA: diva2:375395
Available from: 2010-12-08 Created: 2010-12-08 Last updated: 2017-12-11

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Janerot Sjöberg, BirgittaKimme, Peter

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Janerot Sjöberg, BirgittaKimme, Peter
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Heart CentreClinical Physiology Faculty of Health SciencesAnaesthesiologyDepartment of Intensive Care UHL
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European Journal of Echocardiography
Medical Laboratory and Measurements Technologies

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