The effect of pacing-induced heart rate variation on longitudinal and circumferential regional myocardial function after acute beta-blockade a cardiac ultrasound study
2000 (English)In: European Journal of Echocardiography, ISSN 1525-2167, E-ISSN 1532-2114, Vol. 1, no 3, 184-195 p.Article in journal (Refereed) Published
Aims: To evaluate the effect of acute beta-blockade in combination with differing heart rates on longitudinal and circumferential regional myocardial function using Doppler myocardial imaging and two-dimensional-echocardiography.
Methods and Results: In seven pigs the following echocardiographic indices were measured at baseline, after beta-blockade both without and with atrial pacing: wall thickening fraction, fractional shortening, myocardial peak systolic velocity, transmyocardial velocity gradient and systolic velocity time integral of the posterolateral wall in short-axis view; mitral valve plane excursion, myocardial peak systolic velocity and systolic velocity time integral of the posterolateral wall in an apical five-chamber view. Peak systolic velocities and velocity gradients decreased significantly following acute beta-blockade but no further decay occurred at high heart rate due to pacing. The velocity time integrals and mitral valve plane excursion showed a tendency to decrease following beta-blockade but only after pacing were they significantly reduced. The wall thickening fraction and fractional shortening showed a significant reduction after beta-blockade but no further decay after pacing.
Conclusions: Changes in systolic velocities and velocity gradients were independent of heart rate reduction under high dosage beta-blockade, whereas wall thickening fraction, mitral valve plane excursion and velocity time integrals changed due to pacing.
Place, publisher, year, edition, pages
2000. Vol. 1, no 3, 184-195 p.
doppler myocardial imagingleft ventricular functionbeta-blockadeheart rate variation
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:liu:diva-62976DOI: 10.1053/euje.2000.0030OAI: oai:DiVA.org:liu-62976DiVA: diva2:375395