liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Seroprevalence of Borrelia IgG antibodies among young Swedish children in relation to reported tick bites, symptoms and previous treatment for Lyme borreliosis: a population-based survey
Falun General Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-3993-9985
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Infectious Diseases in Östergötland.
2010 (English)In: ARCHIVES OF DISEASE IN CHILDHOOD, ISSN 0003-9888, Vol. 95, no 12, 1013-1016 p.Article in journal (Refereed) Published
Abstract [en]

Background Lyme borreliosis (LB) is the most common tickborne infection in Sweden and the seroprevalence of Borrelia immunoglobulin G (IgG) antibodies varies between 2% and 26%. The seroprevalence in young Swedish children is unknown and the relation to clinical data has not been previously studied. Objective To determine the seroprevalence of Borrelia IgG antibodies in serum of young Swedish children and to relate it to gender, geographical location, reported tick bites, symptoms and previous treatment for LB. Methods 2000 healthy 5-year-old children (n=2000) were randomly selected from among participants of a larger prospective population-based study, the ABIS (All Babies in Southeast Sweden) study. Serum samples were collected and a Borrelia specific ELISA test (Dako) were performed for IgG antibody detection. Clinical data were collected from questionnaires completed by the parents. Results The seroprevalence of Borrelia IgG antibodies was 3.2% (64/2000). Previous tick bite had been noted in 66% of these seropositive children but the majority (94%) had not previously been treated for LB. In addition, another 55 children reported a history of LB but were negative to Borrelia IgG antibodies in serum. Many of these seronegative children had received treatment for erythema migrans (n=24), which is a clinical diagnosis. Whether children were correctly treated or overtreated for LB is however unknown. No differences in gender, geographical location or reported tick bites were found when comparing Borrelia-seropositive children (n=64) and seronegative children with previous LB (n=55). Conclusion This population-based study demonstrates a Borrelia IgG antibody seroprevalence of 3.2% in young Swedish children. Very few of these seropositive children report previous symptoms or treatment for LB. Thus the findings suggest that exposure to the Borrelia spirochaete (with subsequent antibody response in serum) does occur in young children, mostly without giving rise to clinical LB. Future studies on cell-mediated immune responses are needed to investigate explanatory immunological mechanisms.

Place, publisher, year, edition, pages
BMJ Publishing Group , 2010. Vol. 95, no 12, 1013-1016 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-63160DOI: 10.1136/adc.2010.183624ISI: 000284619100014OAI: oai:DiVA.org:liu-63160DiVA: diva2:376658
Note
Original Publication: Barbro H Skogman, Christina Ekerfelt, Johnny Ludvigsson and Pia Forsberg, Seroprevalence of Borrelia IgG antibodies among young Swedish children in relation to reported tick bites, symptoms and previous treatment for Lyme borreliosis: a population-based survey, 2010, ARCHIVES OF DISEASE IN CHILDHOOD, (95), 12, 1013-1016. http://dx.doi.org/10.1136/adc.2010.183624 Copyright: BMJ Publishing Group http://group.bmj.com/Available from: 2010-12-13 Created: 2010-12-13 Last updated: 2013-08-29

Open Access in DiVA

fulltext(212 kB)291 downloads
File information
File name FULLTEXT01.pdfFile size 212 kBChecksum SHA-512
0d2b3c9c42a7041cd4f066936bb14566cb14409249cd751eb160d2e912b54546494202dc018a7709a011005d985125f8aab0a1a9cf17f8614e311d5882a3ce4d
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Ekerfelt, ChristinaLudvigsson, JohnnyForsberg, Pia

Search in DiVA

By author/editor
Ekerfelt, ChristinaLudvigsson, JohnnyForsberg, Pia
By organisation
Clinical ImmunologyFaculty of Health SciencesPediatricsDepartment of Paediatrics in LinköpingInfectious DiseasesDepartment of Infectious Diseases in Östergötland
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 291 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 221 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf