liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Downregulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome
Sichuan University.
Sichuan University.
Sichuan University.
Sichuan University.
Show others and affiliations
2010 (English)In: COLORECTAL DISEASE, ISSN 1462-8910, Vol. 12, no 12, 1213-1218 p.Article in journal (Refereed) Published
Abstract [en]

Objective To evaluate the clinical significance of caspase-9 mRNA expression and investigate its prognostic value in stage II colorectal cancer. Method Quantitative real-time RT-PCR was used to analyse caspase-9 mRNA expression in cancer tissue and corresponding normal mucosa from 120 patients. Results Compared with normal mucosa, the expression of caspase-9 mRNA was found to be downregulated in cancer tissue (P = 0.001). Poorly differentiated cancer showed lower mRNA expression than cancer with greater differentiation (P = 0.031). The Kaplan-Meier survival analysis demonstrated that patients with downregulated caspase-9 showed a worse overall survival (P = 0.012) and disease-free survival (P = 0.022). Coxs proportional hazards regression model confirmed that expression of caspase-9 was the strongest prognostic factor in stage II colorectal cancer. Conclusion The mRNA expression of caspase-9 can be used as an independent prognostic factor for patients with stage II colorectal cancer.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 12, no 12, 1213-1218 p.
Keyword [en]
Stage II, colorectal cancer, caspase-9, apoptosis, prognostic factor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-63158DOI: 10.1111/j.1463-1318.2009.02009.xISI: 000284167900007OAI: oai:DiVA.org:liu-63158DiVA: diva2:376660
Available from: 2010-12-13 Created: 2010-12-13 Last updated: 2010-12-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Sun, Xiao-Feng

Search in DiVA

By author/editor
Sun, Xiao-Feng
By organisation
Oncology Faculty of Health SciencesDepartment of Oncology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 68 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf