Downregulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome
2010 (English)In: COLORECTAL DISEASE, ISSN 1462-8910, Vol. 12, no 12, 1213-1218 p.Article in journal (Refereed) Published
Objective To evaluate the clinical significance of caspase-9 mRNA expression and investigate its prognostic value in stage II colorectal cancer. Method Quantitative real-time RT-PCR was used to analyse caspase-9 mRNA expression in cancer tissue and corresponding normal mucosa from 120 patients. Results Compared with normal mucosa, the expression of caspase-9 mRNA was found to be downregulated in cancer tissue (P = 0.001). Poorly differentiated cancer showed lower mRNA expression than cancer with greater differentiation (P = 0.031). The Kaplan-Meier survival analysis demonstrated that patients with downregulated caspase-9 showed a worse overall survival (P = 0.012) and disease-free survival (P = 0.022). Coxs proportional hazards regression model confirmed that expression of caspase-9 was the strongest prognostic factor in stage II colorectal cancer. Conclusion The mRNA expression of caspase-9 can be used as an independent prognostic factor for patients with stage II colorectal cancer.
Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 12, no 12, 1213-1218 p.
Stage II, colorectal cancer, caspase-9, apoptosis, prognostic factor
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-63158DOI: 10.1111/j.1463-1318.2009.02009.xISI: 000284167900007OAI: oai:DiVA.org:liu-63158DiVA: diva2:376660