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Surface immobilized zoledronate improves screw fixation in rat bone: A new method for the coating of metal implants
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
Gothenburg University.
2010 (English)In: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, ISSN 0957-4530, Vol. 21, no 11, 3029-3037 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies show that surface immobilized bisphosphonates improve the fixation of stainless steel screws in rat tibia after 2-8 weeks of implantation. We report here about the immobilization of a potent bisphosphonate, zoledronate, to crosslinked fibrinogen by the use of another technique, i.e. ethyl-dimethyl-aminopropylcarbodiimide (EDC)/imidazole immobilization. Bone fixation of zoledronate-coated screws was compared to screws coated with crosslinked fibrinogen only and ditto with EDC/N-hydroxy-succinimide immobilized pamidronate. Fixation in rat tibia was evaluated by a pull-out test at either 2 or 6 weeks after implantation. Both bisphosphonate coatings increased the pull-out force at both time points, and zoledronate showed a significantly higher pull-out force than pamidronate. To further evaluate the new coating technique we also performed a morphometric study, focusing on the area surrounding the implant. The zoledronate coating resulted in an increased bone density around the screws compared to controls. No pronounced increase was seen around the pamidronate coated screws. Together, the results demonstrate the possibility of obtaining a significant local therapeutic effect with minute amounts of surface immobilized zoledronate.

Place, publisher, year, edition, pages
Springer Science Business Media , 2010. Vol. 21, no 11, 3029-3037 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-63148DOI: 10.1007/s10856-010-4154-xISI: 000284074500014OAI: oai:DiVA.org:liu-63148DiVA: diva2:376671
Note
The original publication is available at www.springerlink.com: Therese Andersson, Fredrik Agholme, Per Aspenberg and Pentti Tengvall, Surface immobilized zoledronate improves screw fixation in rat bone: A new method for the coating of metal implants, 2010, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, (21), 11, 3029-3037. http://dx.doi.org/10.1007/s10856-010-4154-x Copyright: Springer Science Business Media http://www.springerlink.com/ Available from: 2010-12-13 Created: 2010-12-13 Last updated: 2010-12-30

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Andersson, ThereseAgholme, FredrikAspenberg, PerTengvall, Pentti

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Department of Clinical and Experimental MedicineFaculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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CiteExportLink to record
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