HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen
2010 (English)In: VACCINE, ISSN 0264-410X, Vol. 28, no 47, 7556-7562 p.Article in journal (Refereed) Published
There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-gamma, TNF-alpha, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.
Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 28, no 47, 7556-7562 p.
HMGB-1 peptides, Adjuvants, Vaccine, Immunotherapy, Dendritic cells
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-63143DOI: 10.1016/j.vaccine.2010.08.054ISI: 000284435500017OAI: oai:DiVA.org:liu-63143DiVA: diva2:376675