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HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen
University of California.
University of Sao Paulo.
University of California.
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
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2010 (English)In: VACCINE, ISSN 0264-410X, Vol. 28, no 47, 7556-7562 p.Article in journal (Refereed) Published
Abstract [en]

There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-gamma, TNF-alpha, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 28, no 47, 7556-7562 p.
Keyword [en]
HMGB-1 peptides, Adjuvants, Vaccine, Immunotherapy, Dendritic cells
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-63143DOI: 10.1016/j.vaccine.2010.08.054ISI: 000284435500017OAI: oai:DiVA.org:liu-63143DiVA: diva2:376675
Available from: 2010-12-13 Created: 2010-12-13 Last updated: 2014-06-04

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Larsson, Marie

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