Association studies on INS and IRS1polymorphisms: IRS1 G972R is associated with increased prostate cancer risk
2008 (English)In: Prostate Cancer and Prostatic Diseases, ISSN 1365-7852Article in journal (Refereed) Submitted
We study the G972R polymorphism in the Insulin receptor substrate 1 gene (IRS1) and the +1127 PstI polymorphism of the Insulin gene (INS), in 120 and 151, respectively, incidentally discovered, histologically verified prostate cancers, and in 185 healthy control subjects. The number of IRS1 R allele was found to be significantly associated with increased risk of prostate cancer. Analysis of the INS +1127 PstI polymorphism shows no significant differences between cases and controls. We conclude that subjects carrying one or two R-alleles at the IRS1 G972R polymorphic site are at an elevated risk of developing prostate cancer.
Place, publisher, year, edition, pages
IRS1, G972R, INS, Insulin, prostate cancer
National CategoryCancer and Oncology
IdentifiersURN: urn:nbn:se:liu:diva-15098OAI: oai:DiVA.org:liu-15098DiVA: diva2:37893