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Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
Karolinska University Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
2010 (English)In: INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, Vol. 37, no 6, 1547-1554 p.Article in journal (Refereed) Published
Abstract [en]

The purpose was to study the prognostic and predictive roles of DNA protein kinase catalytic subunit (DNA-PKcs), Ku70/80 and p53 for the effect of radiotherapy in breast cancer patients Protein expressions of Ku70/80, DNA-PKcs and p53 were examined using immunohistochemistry in tumours from 224 breast cancer patients, who were randomised to receive post-operative radiotherapy or adjuvant chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) One hundred and twenty-nine (60%) of the tumours had low expression of Ku70180, 122 (57%) had low expression of DNA-PKcs and 65 (30%) had altered p53 expression None of the proteins were indicative to the prognosis of local recurrence-free survival Even though the expression of Ku70/80 and DNA-PKcs correlated well, they were not associated with treatment outcome in the same way Low expression of Ku70/80 predicted good effect of radiotherapy (RR=0 31, 95% CI 0 13-0 76, p=0 01) In contrast, the greatest benefit of radiotherapy over chemotherapy was seen in patients with high DNA-PKcs expression (RR=0 25, 95% CI 0 07-0 84, p=0 02) Altered p53 expression predicted poor response to radiotherapy We believe that the results reflect the different roles of DNA-PKcs and Ku70/80 in repair and cell death regulation after DNA damage These differences could be of importance when developing drugs that target DNA repair

Place, publisher, year, edition, pages
Spandidos Publications , 2010. Vol. 37, no 6, 1547-1554 p.
Keyword [en]
radiotherapy, breast cancer DNA-PK Ku70/80, p53
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-63394DOI: 10.3892/ijo_00000808ISI: 000284922700021OAI: oai:DiVA.org:liu-63394DiVA: diva2:379150
Available from: 2010-12-17 Created: 2010-12-17 Last updated: 2014-09-19

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Söderlund, KarinMarie Stenmark, Askmalm

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