Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer
2010 (English)In: INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, Vol. 37, no 6, 1547-1554 p.Article in journal (Refereed) Published
The purpose was to study the prognostic and predictive roles of DNA protein kinase catalytic subunit (DNA-PKcs), Ku70/80 and p53 for the effect of radiotherapy in breast cancer patients Protein expressions of Ku70/80, DNA-PKcs and p53 were examined using immunohistochemistry in tumours from 224 breast cancer patients, who were randomised to receive post-operative radiotherapy or adjuvant chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) One hundred and twenty-nine (60%) of the tumours had low expression of Ku70180, 122 (57%) had low expression of DNA-PKcs and 65 (30%) had altered p53 expression None of the proteins were indicative to the prognosis of local recurrence-free survival Even though the expression of Ku70/80 and DNA-PKcs correlated well, they were not associated with treatment outcome in the same way Low expression of Ku70/80 predicted good effect of radiotherapy (RR=0 31, 95% CI 0 13-0 76, p=0 01) In contrast, the greatest benefit of radiotherapy over chemotherapy was seen in patients with high DNA-PKcs expression (RR=0 25, 95% CI 0 07-0 84, p=0 02) Altered p53 expression predicted poor response to radiotherapy We believe that the results reflect the different roles of DNA-PKcs and Ku70/80 in repair and cell death regulation after DNA damage These differences could be of importance when developing drugs that target DNA repair
Place, publisher, year, edition, pages
Spandidos Publications , 2010. Vol. 37, no 6, 1547-1554 p.
radiotherapy, breast cancer DNA-PK Ku70/80, p53
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-63394DOI: 10.3892/ijo_00000808ISI: 000284922700021OAI: oai:DiVA.org:liu-63394DiVA: diva2:379150