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Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times
Linköping University, Department of Biomedicine and Surgery, Division of surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
Linköping University, Department of Biomedicine and Surgery, Division of surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
2010 (English)In: MICROVASCULAR RESEARCH, ISSN 0026-2862, Vol. 80, no 3, 412-416 p.Article in journal (Refereed) Published
Abstract [en]

Tissue occlusion and the hyperaemic response upon reperfusion can be used as a tool to assess microvascular function in various vascular diseases. Currently, laser Doppler flowmetry (LDF) is applied most often to measure hyperaemic responses. In this study, we have applied tissue viability imaging (TiVi) and LDF to measure the change in red blood cell concentration and perfusion in the skin after occlusions of the forearm with increasing duration. We have found that there is a strong correlation between the changes in perfusion and red blood cell (RBC) concentration during post-occlusive hyperaemia (perfusion: r = 0.80; RBC concentration: r = 0.94). This correlation increases with longer occlusion durations (1, 5 and 10 min). Furthermore, for both perfusion and RBC concentration, the maximum responses (perfusion: r(2) = 0.59; RBC concentration: r(2) = 0.78) and the recovery times (perfusion: r(2) = 0.62; RBC concentration: r(2) = 0.91) increase linearly with the duration of the occlusion. Maximum responses and recovery times were more reproducible for RBC concentration (as measured with TiVi) than for perfusion (as measured with LDF). These results show that perfusion and RBC concentration are related during post-occlusive hyperaemia and that TiVi can be used as a tool in the assessment of hyperaemic responses that has advantages in terms of reproducibility, sensitivity and ease of use.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam , 2010. Vol. 80, no 3, 412-416 p.
Keyword [en]
Occlusion, Hyperaemia, Laser Doppler, Tissue viability imaging, Perfusion, Red blood cell concentration, Polarisation light spectroscopy, Ischemia, Reperfusion
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-63383DOI: 10.1016/j.mvr.2010.07.008ISI: 000284678300016OAI: oai:DiVA.org:liu-63383DiVA: diva2:379173
Note
Original Publication: Simon Farnebo, Johan Thorfinn, Joakim Henricson and Erik Tesselaar, Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times, 2010, MICROVASCULAR RESEARCH, (80), 3, 412-416. http://dx.doi.org/10.1016/j.mvr.2010.07.008 Copyright: Elsevier Science B.V., Amsterdam http://www.elsevier.com/ Available from: 2010-12-17 Created: 2010-12-17 Last updated: 2010-12-22

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Farnebo, SimonThorfinn, JohanHenricson, JoakimTesselaar, Erik

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