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Antidepressant medication prevents suicide in depression
Karolinska University Hospital.
Karolinska Institute.
University Uppsala Hospital.
Karolinska University Hospital.
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2010 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 122, no 6, 454-460 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Ecological studies have demonstrated a substantial decrease in suicide in parallel with an increasing use of antidepressants. To investigate on the individual level the hypothesis that antidepressant medication was a causal factor. Method: Data on the toxicological detection of antidepressants in 18 922 suicides in Sweden 1992-2003 were linked to registers of psychiatric hospitalization as well as registers with sociodemographic data. Results: The probability for the toxicological detection of an antidepressant was lowest in the non-suicide controls, higher in suicides, and even higher in suicides that had been psychiatric inpatients but excluding those who had been in-patients for the treatment of depression. Conclusion: The finding that in-patient care for depression did not increase the probability of the detection of antidepressants in suicides is difficult to explain other than by the assumption that a substantial number of depressed individuals were saved from suicide by postdischarge treatment with antidepressant medication.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 122, no 6, 454-460 p.
Keyword [en]
suicide; prevention; depression; antidepressants
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-63967DOI: 10.1111/j.1600-0447.2010.01561.xISI: 000284665700006OAI: diva2:384470
Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2011-01-10

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Ahlner, Johan
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Clinical Pharmacology Faculty of Health Sciences
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