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Glomerular filtration rate is increased in burn patients
Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Intensive Care UHL.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
Linköping University, Department of Medical and Health Sciences, Anesthesiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Intensive Care UHL.
Linköping University, Department of Medical and Health Sciences, Anesthesiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Intensive Care UHL.
2010 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 36, no 8, 1271-1276 p.Article in journal (Refereed) Published
Abstract [en]

Urinary output a key parameter guiding fluid resuscitation in burn trauma is an inadequate measure of renal function In this study the clearance of iohexol (CL) was used to follow the glomerular filtration rate during the first week after burn Nineteen adults with major burns received an intravenous bolus injection of iohexol every other day Plasma concentration of iohexol was measured over 4 h and CL was calculated by a one compartment kinetic model The results were compared to the CL as obtained by a two compartment model and also to the CL measured in 10 healthy controls The results show that CL values for burn patients were high The first day after burn median CL was 155 mL/min/1 73 m(2) (range 46-237) which exceeded that for the controls (mean 117 mL/min/1 73 m(2) P less than 0 01) However on day 7 the CL approached the expected baseline (mean 122 mL/min/1 73 m(2)) CL was 10% lower when calculated from two compartment kinetics and a correction factor of 0 9 was applied to all results obtained by the one compartment calculations to give results comparable to those from the two compartment kinetics In conclusion CL is increased early after burn The mechanism is unclear but it parallels the period of vascular dysfunction and increased cardiac output

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 36, no 8, 1271-1276 p.
Keyword [en]
Burns; Iohexol clearance; Kidney function; Glomerular filtration rate; Organ dysfunction; Renal clearance; Resuscitation
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:liu:diva-63966DOI: 10.1016/j.burns.2010.03.012ISI: 000284571000018PubMedID: 20547000OAI: oai:DiVA.org:liu-63966DiVA: diva2:384473
Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2015-06-09Bibliographically approved

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Zdolsek, JoachimKågedal, BertilLisander, BjörnHahn, Robert

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Department of Intensive Care UHLClinical ChemistryFaculty of Health SciencesDepartment of Clinical ChemistryAnesthesiology
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