liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Importance of Disrupted Intestinal Barrier in Inflammatory Bowel Diseases
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
2011 (English)In: INFLAMMATORY BOWEL DISEASES, ISSN 1078-0998, Vol. 17, no 1, 362-381 p.Article, review/survey (Refereed) Published
Abstract [en]

The current paradigm of inflammatory bowel diseases (IBD), both Crohns disease (CD) and ulcerative colitis (UC), involves the interaction between environmental factors in the intestinal lumen and inappropriate host immune responses in genetically predisposed individuals. The intestinal mucosal barrier has evolved to maintain a delicate balance between absorbing essential nutrients while preventing the entry and responding to harmful contents. In IBD, disruptions of essential elements of the intestinal barrier lead to permeability defects. These barrier defects exacerbate the underlying immune system, subsequently resulting in tissue damage. The epithelial phenotype in active IBD is very similar in CD and UC. It is characterized by increased secretion of chloride and water, leading to diarrhea, increased permeability via both the transcellular and paracellular routes, and increased apoptosis of epithelial cells. The main cytokine that seems to drive these changes is tumor necrosis factor alpha in CD, whereas interleukin (IL)-13 may be more important in UC. Therapeutic restoration of the mucosal barrier would provide protection and prevent antigenic overload due to intestinal "leakiness. Here we give an overview of the key players of the intestinal mucosal barrier and review the current literature from studies in humans and human systems on mechanisms underlying mucosal barrier dysfunction in IBD.

Place, publisher, year, edition, pages
John Wiley andamp; Sons , 2011. Vol. 17, no 1, 362-381 p.
Keyword [en]
intestinal mucosal barrier, intestinal permeability, CD, UC, IBD
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-64239DOI: 10.1002/ibd.21403ISI: 000285258500044OAI: diva2:388119
Available from: 2011-01-17 Created: 2011-01-17 Last updated: 2014-10-24

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Salim, Sa´adSöderholm, Johan D
By organisation
SurgeryFaculty of Health SciencesDepartment of Surgery in Östergötland
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 57 hits
ReferencesLink to record
Permanent link

Direct link