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Differences in Cerebral Extracellular Response of Interleukin-1 beta, Interleukin-6, and Interleukin-10 After Subarachnoid Hemorrhage or Severe Head Trauma in Humans
Östergötlands Läns Landsting, Reconstruction Centre, Department of Neurosurgery UHL.
Linköping University, Department of Clinical and Experimental Medicine, Neurosurgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Dermatology and Venerology in Östergötland.
Östergötlands Läns Landsting, Sinnescentrum, Department of Neurosurgery UHL.
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2011 (English)In: NEUROSURGERY, ISSN 0148-396X, Vol. 68, no 1, 12-19 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Microdialysis has become a routine method for biochemical surveillance of patients in neurosurgical intensive care units. OBJECTIVE: To analyze the intracerebral extracellular levels of 3 interleukins (ILs) during the 7 days after major subarachnoid hemorrhage or traumatic brain injury). METHODS: Microdialysate from 145 severely injured neurosurgical intensive care unit patients (88 with subarachnoid hemorrhage, 57 with traumatic brain injury) was collected every 6 hours for 7 days. The concentrations of IL-1 beta and IL-6 were determined by fluorescence multiplex bead technology, and IL-10 was determined by enzyme-linked immunosorbent assay. RESULTS: Presented are the response patterns of 3 ILs during the first week after 2 different types of major brain injury. These patterns are different for each IL and also differ with respect to the kind of pathological impact. For both IL-1 beta and IL-6, the initial peaks (mean values for all patients at day 2 being 26.9 +/- 4.5 and 4399 +/- 848 pg/mL, respectively) were followed by a gradual decline, with IL-6 values remaining 100-fold higher compared with IL-1 beta. Female patients showed a stronger and more sustained response. The response of IL-10 was different, with mean values less than 23 pg/mL and with no significant variation between any of the postimpact days. For all 3 ILs, the responses were stronger in subarachnoid hemorrhage patients. The study also indicates that under normal conditions, IL-1 beta, IL-6, and IL-10 are present only at very low concentrations or not at all in the extracellular space of the human brain. CONCLUSION: This is the first report presenting in some detail the human cerebral response of IL-1 beta, IL-6, and IL-10 after subarachnoid hemorrhage and traumatic brain injury. The 3 ILs have different reaction patterns, with the response of IL-1 beta and IL-6 being related to the type of cerebral damage sustained, whereas the IL-10 response was less varied.

Place, publisher, year, edition, pages
Williams and Wilkins , 2011. Vol. 68, no 1, 12-19 p.
Keyword [en]
Interleukins, Interleukin-1, Interleukin-6, Interleukin-10, Microdialysis, Subarachnoid hemorrhage, Traumatic brain injury
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-64237DOI: 10.1227/NEU.0b013e3181ef2a40ISI: 000285288200018OAI: diva2:388125
Available from: 2011-01-17 Created: 2011-01-17 Last updated: 2012-04-02

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Åneman, OscarSjögren, FlorenceHillman, Jan
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Department of Neurosurgery UHLNeurosurgeryFaculty of Health SciencesDermatology and VenerologyDepartment of Dermatology and Venerology in ÖstergötlandDepartment of Neurosurgery UHL
Medical and Health Sciences

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