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Interstitial concentration of serotonin is increased in myalgic human trapezius muscle during rest, repetitive work and mental stress - an in vivo microdialysis study
Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-2530-4126
Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Östergötlands Läns Landsting, Heart and Medicine Centre, Occupational and Environmental Medicine Centre. Linköping University, Faculty of Health Sciences.
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2010 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 70, no 7, 478-486 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The pathophysiology of trapezius myalgia is not fully elucidated. Serotonin (5-HT) is involved in modulation of nociception and hyperalgesia. Our aim was to compare the interstitial 5-HT levels of the trapezius muscle in women with chronic trapezius myalgia and in pain-free controls.

MATERIALS AND METHODS: Microdialysate of the trapezius muscle collected every 20 minutes during rest, work (100 min) and stress (20 min) was used to study the dynamics of 5-HT in women with chronic trapezius myalgia (MYA; n=18) and in pain-free controls (CON; n=30).

RESULTS: MYA had higher levels of 5-HT than CON at baseline, during repetitive work, during mental stress and during recovery. There were no significant time effects on 5-HT levels.

CONCLUSION: 5-HT has the potential of a biomarker of chronic myalgia. Elevated levels of 5-HT may be involved in maintenance of habitual chronic pain and might contribute to increased pain during exercise by facilitating the effect of released algesic substances linked to such muscle demands.

Place, publisher, year, edition, pages
Taylor and Francis , 2010. Vol. 70, no 7, 478-486 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-64253DOI: 10.3109/00365513.2010.511257ISI: 000283127000003OAI: oai:DiVA.org:liu-64253DiVA: diva2:388267
Available from: 2011-01-21 Created: 2011-01-17 Last updated: 2017-12-11Bibliographically approved

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Ghafouri, BijarLarsson, BrittSjörs, AnnaLeandersson, PerGerdle, Björn

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Scandinavian Journal of Clinical and Laboratory Investigation
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