liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Two-Year Outcomes in Thoracic Transplant Recipients After Conversion to Everolimus With Reduced Calcineurin Inhibitor Within a Multicenter, Open-Label, Randomized Trial
Oslo University Hospital.
Rigshospital, Copenhagen, Denmark .
Aarhus University Hospital.
Sahlgrens University Hospital.
Show others and affiliations
2010 (English)In: TRANSPLANTATION, ISSN 0041-1337, Vol. 90, no 12, 1581-1589 p.Article in journal (Refereed) Published
Abstract [en]

Background. Use of the mammalian target of rapamycin inhibitor everolimus with an accompanying reduction in calcineurin inhibitor (CNI) exposure has shown promise in preserving renal function in maintenance thoracic transplant patients, but robust, long-term data are required. Methods. In a prospective, open-label, multicenter study, thoracic transplant recipients more than or equal to 1 year posttransplant with mild-to-moderate renal insufficiency were randomized to continue their current CNI-based immunosuppression or convert to everolimus with predefined CNI exposure reduction. After a 12-month core trial, patients were followed up to month 24 after randomization. Results. Of 245 patients who completed the month 12 visit, 235 patients (108 everolimus and 127 controls) entered the 12-month extension phase. At month 24, mean measured glomerular filtration rate had increased by 3.2 +/- 12.3 mL/min from the point of randomization in everolimus-treated patients and decreased by 2.4 +/- 9.0 mL/min in controls (Pandlt;0.001), a difference that was significant within both the heart and lung transplant subpopulations. During months 12 to 24, 5.6% of everolimus patients and 3.1% of controls experienced biopsy-proven acute rejection (P=0.76). There were no significant differences in the rate of adverse events or serious adverse events (including pneumonia) between groups during months 12 to 24. Conclusions. Converting maintenance thoracic transplant recipients to everolimus with low-exposure CNI results in a renal benefit that is sustained to 2 years postconversion, with significantly improved measured glomerular filtration rate in both heart and lung transplant patients. Despite reductions of more than 50% in CNI exposure, there was no marked loss of efficacy. The safety profile of the everolimus-based regimen was acceptable.

Place, publisher, year, edition, pages
Williams and Wilkins , 2010. Vol. 90, no 12, 1581-1589 p.
Keyword [en]
Everolimus, Certican, CNI, Cyclosporine A, Tacrolimus, Renal impairment
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-64232DOI: 10.1097/TP.0b013e3181fd01b7ISI: 000285377100052OAI: diva2:388435
Available from: 2011-01-17 Created: 2011-01-17 Last updated: 2011-01-17

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Jansson, Kjell
By organisation
CardiologyFaculty of Health SciencesDepartment of Cardiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 45 hits
ReferencesLink to record
Permanent link

Direct link