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A randomised feasibility/phase II study (SBG 2004-1) with dose-dense/tailored epirubicin, cyclophoshamide (EC) followed by docetaxel (T) or fixed dosed dose-dense EC/T versus T, doxorubicin and C (TAC) in node-positive breast cancer
Karolinska Institute.
Umea University Hospital.
Sundsvall Hospital.
Gavle Hopsital.
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2011 (English)In: ACTA ONCOLOGICA, ISSN 0284-186X, Vol. 50, no 1, 35-41 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to evaluate the feasibility of tailored and dose-dense epirubicin and cyclophosphamide followed by docetaxel as adjuvant breast cancer therapy. Material and methods. Patients with node-positive breast cancer received either four cycles of biweekly and tailored EC (epirubicin 38-60-75-90-105-120 mg/m(2), cyclophosphamide 450-600-900-1200 mg/m(2)) followed by four cycles of docetaxel (60-75-85-100 mg/m(2)) (arm A) or the same regimen with fixed doses (E90C600 x 4 -andgt; T-75 x 4) (arm B) or docetaxel, doxorubicin and cyclophosphamide (T(75)A(50)C(500)) every three weeks for six cycles (arm C). All patients received G-CSF support and prophylactic ciprofloxacin. Results. One-hundred and twenty-four patients were randomised in the study. In the A, B and C arm, 17% 19% and 3% of the patients had one or more cycles delayed due to side-effects whereas 24%, 5% and 15% experienced a grade 3 infection or febrile neutropenia. After the introduction of an extra week between the EC and T parts in the A and B arms, grade 3 hand-foot-skin reactions were reduced from 5 to 0.2%. Twenty-nine percent (A and B) and 20% (C) of the patients were hospitalised due to side-effects. Discussion. Dose-dense and tailored EC/T can be given with manageable toxicity and is after adjustment presently studied in the phase III Panther trial.

Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 50, no 1, 35-41 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-64585DOI: 10.3109/0284186X.2010.535847ISI: 000285554200005OAI: oai:DiVA.org:liu-64585DiVA: diva2:392791
Available from: 2011-01-28 Created: 2011-01-28 Last updated: 2011-01-28

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CiteExportLink to record
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  • apa
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