Superficial Blood flow Following Photodynamic Therapy of Malignant Skin Tumours Measured by Laser Doppler Perfusion Imaging
1997 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 136, no 2, 184-189 p.Article in journal (Refereed) Published
Laser Doppler perfusion imaging offers a new modality for in vivo monitoring of the superficial blood perfusion in biological tissue. In this study, the superficial blood perfusion of malignant nonmelanoma skin tumours and the surrounding normal skin was measured in conjunction with photodynamic therapy (PDT) using topical ò–aminolaevulinic acid (ALA)–induced protoporphyrin IX as a photosensitizer. The results clearly show that, in contradiction to PDT with the intravenously administered photosensitizer photofrin. no direct vascular damage can be seen. With the topical sensitization the blood perfusion is increased immediately after the treatment irradiation. The increased blood flow is seen up to a week after treatment, in a similiar way as for an inflammatory reaction. Despite this, all basal cell carcinoma and squamous cell carcinoma in situ lesions in this study healed without any sign of residual tumour after the treatment, suggesting an efficient direct tumour cell destruction induced by PDT.
Place, publisher, year, edition, pages
1997. Vol. 136, no 2, 184-189 p.
National CategoryMedical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:liu:diva-64705DOI: 10.1046/j.1365-2133.1997.d01-1166.xOAI: oai:DiVA.org:liu-64705DiVA: diva2:394174