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Molecular recognition: Design of "keys"
Cranfield University, Institute Biosci and Technology, Silsoe MK45 4DT, Beds, England; .
Cranfield University, Institute Biosci and Technology, Silsoe MK45 4DT, Beds, England; .
Cranfield University, UK.ORCID iD: 0000-0002-1815-9699
2002 (English)In: Combinatorial chemistry & high throughput screening, ISSN 1386-2073, E-ISSN 1875-5402, Vol. 5, no 6, 409-427 p.Article, review/survey (Refereed) Published
Abstract [en]

Molecular recognition between molecules is one of the most fundamental processes in biology and chemistry. The recognition process is largely driven by non-covalent forces such as hydrogen bonding, electrostatics, van der Waals forces, pi-pi interactions, and conformational energy. The complementarity between the receptor and substrate is very similar to the "lock and key" function, first described by Emil Fischer over 100 years ago, - the lock being the molecular receptor such as a protein or enzyme and the key being the substrate such as a drug, that is recognized to give a defined receptor-substrate complex. This review focuses on the design of specific ligand systems as "Keys" to enable the induced fit of these keys into the target macromolecules, protein/enzyme (Locks) with particular emphasis on protein recognition.

Place, publisher, year, edition, pages
Bantham Science Publishers Ltd , 2002. Vol. 5, no 6, 409-427 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-65204ISI: 000181710300001OAI: oai:DiVA.org:liu-65204DiVA: diva2:395030
Available from: 2011-02-04 Created: 2011-02-04 Last updated: 2017-12-11

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