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Proinsulin/C-peptide ratio, glucagon and remission in new-onset Type 1 diabetes mellitus in young adults
Uppsala University.
Umea University.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
Karolinska University.
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2011 (English)In: DIABETIC MEDICINE, ISSN 0742-3071, Vol. 28, no 2, 156-161 p.Article in journal (Refereed) Published
Abstract [en]

Pandgt;Aims After initiation of treatment in Type 1 diabetes, a period with lower insulin requirement often follows, reflecting increased insulin sensitivity and improved insulin secretion. We explored if efficiency of proinsulin processing is associated with the remission phenomenon. Methods Seventy-eight patients with new-onset Type 1 diabetes were followed prospectively for 3 years. Daily insulin dosage, HbA(1c), plasma glucose, proinsulin, C-peptide, glucagon concentrations and islet antibodies were determined at diagnosis and after 3, 6, 9, 12, 18, 24, 30 and 36 months. We studied remission, defined as an insulin dose andlt; 0.3 U kg-1 24 h-1 and HbA(1c) within the normal range, in relation to the above-mentioned variables. Results A rise and subsequent decline in plasma proinsulin and C-peptide concentrations was observed. Forty-five per cent of the patients experienced remission at one or more times, characterized by higher proinsulin and C-peptide levels, and lower proinsulin/C-peptide ratios, indicating more efficient proinsulin processing, compared with those not in remission. Non-remission also tended to be associated with higher glucagon values. Patients entering remission were more often men, had higher BMI at diagnosis, but did not differ at baseline with respect to islet antibody titres compared with patients with no remission. Conclusions Remissions after diagnosis of Type 1 diabetes were associated with lower proinsulin/C-peptide ratios, suggesting more efficient proinsulin processing, and tended to have lower glucagon release than non-remissions. This indicates that, in remission, the residual islets maintain a secretion of insulin and glucagon of benefit for control of hepatic glucose production.

Place, publisher, year, edition, pages
Wiley-Blackwell , 2011. Vol. 28, no 2, 156-161 p.
Keyword [en]
C-peptide, glucagon, proinsulin, remission, Type 1 diabetes
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-65565DOI: 10.1111/j.1464-5491.2010.03191.xISI: 000286107000005OAI: diva2:396788
Available from: 2011-02-11 Created: 2011-02-11 Last updated: 2011-02-11

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Arnqvist, Hans
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Cell BiologyFaculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHL
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