An unbiased metagenomic search for infectious agents using monozygotic twins discordantfor chronic fatigue
2011 (English)In: BMC Microbiology, ISSN 1471-2180, Vol. 11, no 2Article in journal (Refereed) Published
Background: Chronic fatigue syndrome is an idiopathic syndrome widely suspected of having an infectious orimmune etiology. We applied an unbiased metagenomic approach to try to identify known or novel infectiousagents in the serum of 45 cases with chronic fatigue syndrome or idiopathic chronic fatigue. Controls were theunaffected monozygotic co-twins of cases, and serum samples were obtained at the same place and time.Results: No novel DNA or RNA viral signatures were confidently identified. Four affected twins and no unaffectedtwins evidenced viremia with GB virus C (8.9% vs. 0%, p = 0.019), and one affected twin had previously undetectedhepatitis C viremia. An excess of GB virus C viremia in cases with chronic fatigue requires confirmation.Conclusions: Current, impairing chronic fatigue was not robustly associated with viremia detectable in serum.
Place, publisher, year, edition, pages
BMC , 2011. Vol. 11, no 2
IdentifiersURN: urn:nbn:se:liu:diva-65704DOI: 10.1186/1471-2180-11-2ISI: 000286331700001OAI: oai:DiVA.org:liu-65704DiVA: diva2:398441
Patrick F Sullivan, Tobias Allander, Fredrik Lysholm, Shan Goh, Bengt Persson, Andreas Jacks, Birgitta Evengård, Nancy L Pedersen and Björn Andersson, An unbiased metagenomic search for infectious agents using monozygotic twins discordantfor chronic fatigue, 2011, BMC Microbiology, (11), 2.
Licensee: BioMed Central