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Lysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophages
Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology. Linköping University, Faculty of Health Sciences.
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2011 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 585, no 4, 623-9 p.Article in journal (Refereed) Published
Abstract [en]

Moderate lysosomal membrane permeabilization (LMP) is an important inducer of apoptosis. Macrophages are professional scavengers and are rich in hydrolytic enzymes and iron. In the present study, we found that LMP by lysosomotropic detergent MSDH resulted in early up-regulation of lysosomal cathepsins, oxidative stress and ferritin up-regulation, and cell death. Lysosomotropic base NH(4)Cl reduced the ferritin induction and oxidative stress in apoptotic cells induced by MSDH. Cysteine cathepsin inhibitors significantly protected cell death and oxidative stress, but had less effect on ferritin induction. We conclude that oxidative stress induced by lysosomal rupture causes ferritin induction with concomitant mitochondrial damage, which are the potential target for prevention of cellular oxidative stress and cell death induced by typical lysosomotropic substances in different disorders.

Place, publisher, year, edition, pages
Elsevier , 2011. Vol. 585, no 4, 623-9 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-65820DOI: 10.1016/j.febslet.2010.12.043ISI: 000287237100007PubMedID: 21219901OAI: oai:DiVA.org:liu-65820DiVA: diva2:399237
Available from: 2011-02-21 Created: 2011-02-21 Last updated: 2017-12-11Bibliographically approved

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Laskar, AmitYuan, XiMingLi, Wei

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