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Antioxidants in the prevention of atherosclerosis
Linköping University, Department of Medicine and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Endocrinology and Gastroenterology UHL.
Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology. Linköping University, Faculty of Health Sciences.
1996 (English)In: Current Opinion in Lipidology, ISSN 0957-9672, E-ISSN 1473-6535, Vol. 7, no 6, 374-80 p.Article in journal (Refereed) Published
Abstract [en]

Four antioxidant treatment modalities against atherosclerosis and coronary heart disease are scrutinized: probucol, beta-carotene, alpha-tocopherol and anti-iron treatment. A pattern seems to have emerged in which some treatments look promising, but others are disappointing. Most published studies of antioxidation in atherosclerosis have been ad-hoc in that the primary endpoint of the study has not been a diagnosis related to atherosclerosis; this may be misleading. The most promising antioxidant seems to be alpha-tocopherol, supported by the results of the Cambridge Heart Antioxidant Study. Probucol has the drawback of decreasing high density lipoprotein concentration and is therefore unlikely to influence atheroma in people. beta-Carotene has been repeatedly shown to be ineffective against coronary heart disease. Anti-iron treatment has not yet been tested in animal models or in man. More has to be learned of the role of antioxidation in atherosclerosis before the effectiveness of this treatment modality can be established.

Place, publisher, year, edition, pages
1996. Vol. 7, no 6, 374-80 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-65832PubMedID: 9117141OAI: diva2:399365
Available from: 2011-02-22 Created: 2011-02-22 Last updated: 2011-03-02Bibliographically approved

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