liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Transient increase in HDL cholesterol during weight gain by hyper-alimentation in healthy subjects
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Endocrinology and Gastroenterology UHL.
County Hospital of Kalmar.
Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL. Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-1680-1000
2011 (English)In: Obesity, ISSN 1930-7381, Vol. 19, no 4, 812-817 p.Article in journal (Refereed) Published
Abstract [en]

Determination of lipid levels is fundamental in cardiovascular risk assessment. We studied the short-term effects of fast food–based hyperalimentation on lipid levels in healthy subjects. Twelve healthy men and six healthy women with a mean age of 26 ± 6.6 years and an aged-matched control group were recruited for this prospective interventional study. Subjects in the intervention group aimed for a body weight increase of 5–15% by doubling the baseline caloric intake by eating at least two fast food–based meals a day in combination with adoption of a sedentary lifestyle for 4 weeks. This protocol induced a weight gain from 67.6 ± 9.1 kg to 74.0 ± 11 kg (P < 0.001). A numerical increase in the levels of high-density lipoprotein (HDL)-cholesterol occurred in all subjects during the study and this was apparent already at the first week in 16/18 subjects (mean increase at week 1: +22.0 ± 16%, range from –7 to +50%), whereas the highest level of HDL during the study as compared with baseline values varied from +6% to +58% (mean +31.6 ± 15%). The intake of saturated fat in the early phase of the trial related positively with the HDL-cholesterol-increase in the second week (r = 0.53, P = 0.028). Although the levels of insulin doubled at week 2, the increase in low-density lipoprotein (LDL)-cholesterol was only +12 ± 17%, and there was no statistically significant changes in fasting serum triglycerides. We conclude that hyperalimentation can induce a fast but transient increase in HDL-cholesterol that is of clinical interest when estimating cardiovascular risk based on serum lipid levels.

Place, publisher, year, edition, pages
Nature Publishing Group , 2011. Vol. 19, no 4, 812-817 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-65894DOI: 10.1038/oby.2010.190ISI: 000288901400023OAI: oai:DiVA.org:liu-65894DiVA: diva2:400062
Note
Original Publication: Torbjörn Lindström, Stergios Kechagias, Martin Carlsson and Fredrik H. Nystrom, Transient increase in HDL cholesterol during weight gain by hyper-alimentation in healthy subjects, 2010, Obesity, (Sept). http://dx.doi.org/10.1038/oby.2010.190 Copyright: NAASO The Obesity Society Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2013-09-10

Open Access in DiVA

fulltext(418 kB)838 downloads
File information
File name FULLTEXT01.pdfFile size 418 kBChecksum SHA-512
14b568b6ff22ef43401cc8a138fddcd358bf118d018992b060c32728f49b7edeb7d16571dca22926f11ef629081681573f1d110dfc2ef85d9c5a9c6258010867
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Lindström, TorbjörnKechagias, StergiosNystrom, Fredrik H.

Search in DiVA

By author/editor
Lindström, TorbjörnKechagias, StergiosNystrom, Fredrik H.
By organisation
Internal MedicineFaculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHLDepartment of Endocrinology and Gastroenterology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 838 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 186 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf