liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Dietary Phytoestrogens and the Risk of Ovarian Cancer in the Womens Lifestyle and Health Cohort Study
Folkhalsan Research Centre.
Linköping University, Department of Clinical and Experimental Medicine, Nutrition. Linköping University, Faculty of Health Sciences.
Karolinska Institute.
University of Helsinki.
Show others and affiliations
2011 (English)In: CANCER EPIDEMIOLOGY BIOMARKERS and PREVENTION, ISSN 1055-9965, Vol. 20, no 2, 308-317 p.Article in journal (Refereed) Published
Abstract [en]

Background: Dietary intake of phytoestrogens has been inversely associated to hormone-dependent cancers, such as prostate and breast cancers. Few studies have investigated the association between ovarian cancer and intake of phytoestrogens. We evaluated the associations between intake of phytoestrogens (isoflavonoids/lignans/coumestrol) and fiber (vegetable/cereal) and risk of ovarian cancer. Methods: In 1991-1992 a prospective population-based cohort study among Swedish women was conducted, including 47,140 women with complete dietary questionnaire data. During follow-up until December 2007, 163 women developed invasive (n = 117) and borderline (n = 46) ovarian cancers. The median follow-up time was 16 years and total person year was 747,178. Cox proportional hazards models were conducted to estimate multivariate risk ratios, 95% CI for associations with risk of ovarian cancer. Results: We found no association between intake of phytoestrogens or fiber and overall ovarian cancer risk. In addition, we found no statistically significant association between intake of specific food items rich in phytoestrogens (berries, nuts, beans/soy, and crisp or whole-grain bread) and ovarian cancer risk overall. Fiber and coumestrol was inversely associated with borderline ovarian cancer, but not with invasive ovarian cancer. Conclusions: We found no association between intake of phytoestrogens or fiber and overall ovarian cancer risk. Impact: Phytoestrogens do not play a major etiologic role in ovarian cancer, at least among women in this Swedish cohort with low bean/soy intake. However, our results of a difference in the effect of fiber or coumestrol between invasive and borderline ovarian cancer need to be evaluated in larger studies.

Place, publisher, year, edition, pages
American Association for Cancer Research Inc , 2011. Vol. 20, no 2, 308-317 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-66145DOI: 10.1158/1055-9965.EPI-10-0752ISI: 000287021400013OAI: diva2:401917
Available from: 2011-03-04 Created: 2011-03-04 Last updated: 2011-03-04

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Löf, Marie
By organisation
NutritionFaculty of Health Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 12 hits
ReferencesLink to record
Permanent link

Direct link