Unfavourable outcome for women in a study of health-related quality of life, social factors, and work disability in Crohn’s disease
2011 (English)In: European Journal of Gastroenterology and Hepathology, ISSN 0954-691X, E-ISSN 1473-5687, Vol. 23, no 8, 671-679 p.Article in journal (Refereed) Published
Objective. The aim was to describe health-related quality of life (HRQL) and social factors, sickness and disability variables in a large population-based cohort of patients with Crohn’s disease (CD).
Methods. HRQL was measured with SF-36 in 497 adult CD patients at three outpatient clinics. Comparisons were made with age-gender-matched background population and with ulcerative colitis (UC). Social factors, employment, sickness compensation, and disability pension for CD, were compared with national population registers.
Results. CD had a greater negative effect on HRQL than did UC. This difference was more pronounced for women. Compared with background population, CD patients had lower educational level, and had a two-fold rise in long-term sickness and disability pension rate. CD women had higher rates of sickness and disability than CD men and were more often living single, though procreation was not affected.
Conclusion. This study characterized the burden of CD in a large population-based cohort. CD had higher impact on HRQL, compared with UC. CD women had worse outcome in subjective health status, but not in objective assessment of disease activity. Women also had higher rates of sickness, disability pension, and single living. The mechanism underlying the gender-related inequalities in outcome for CD warrants further elucidation.
Place, publisher, year, edition, pages
Lippincott Wilkins and Williams , 2011. Vol. 23, no 8, 671-679 p.
Crohn’s disease; inflammatory bowel disease; health-related quality of life; disability; sickness; social factors
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-66248DOI: 10.1097/MEG.0b013e328346f622ISI: 000292503100006OAI: oai:DiVA.org:liu-66248DiVA: diva2:402698