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Randomized phase II study of gemcitabine and carboplatin +/- sequential docetaxel in non-small cell lung cancer
Karolinska University Hospital.
Linköping University, Department of Medicine and Health Sciences, Pulmonary Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Respiratory Medicine UHL.
University Lund Hospital.
2011 (English)In: LUNG CANCER, ISSN 0169-5002, Vol. 71, no 2, 178-181 p.Article in journal (Refereed) Published
Abstract [en]

Sequential administration of chemotherapeutic drugs might have advantages: additive toxicity is avoided and the individual drugs can be given in full dosages. The Swedish group earlier found the combination of gemcitabine and carboplatin to be effective and with acceptable toxicity. The group therefore decided to add docetaxel in a sequential way in a randomized phase II study. Patients were randomized to either gemcitabine or carboplatin for six cycles or the same regimen for three cycles followed by weekly single agent docetaxel. The primary objective was time to progression (UP). One hundred and twenty-three patients with performance status WHO 0-2 and with earlier un-treated non-small cell lung cancer with measurable stage IIIB disease, not amenable to curative treatment, or stage IV disease without known metastatic spread to the CNS, were enrolled. Hematological toxicity was more common in the GC group but clinically significant bleeding or leucopenic fever occurred only in a minority of patients. No complete responses were noted. Partial response (PR) was observed in 19.3% and 20.8% in the GC and GCD group, respectively. Progression-free survival was 5.6 and 4.8 months and overall survival time 10.6 and 10.1 months in the GC and GCD groups, respectively. Thus, sequential treatment with docetaxel after treatment with gemcitabine and carboplatin did not improve time to progression, response rates, or overall survival.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2011. Vol. 71, no 2, 178-181 p.
Keyword [en]
Non-small cell lung cancer, Sequential treatment, Randomized phase II study, Gemcitabine, Docetaxel
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-66287DOI: 10.1016/j.lungcan.2010.05.007ISI: 000287769400009OAI: diva2:403170
Available from: 2011-03-11 Created: 2011-03-11 Last updated: 2011-03-11

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Sederholm, Christer
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Pulmonary MedicineFaculty of Health SciencesDepartment of Respiratory Medicine UHL
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