Age Aspects of Demography, Pathology and Survival Assessment in Colorectal Cancer
2010 (English)In: ANTICANCER RESEARCH, ISSN 0250-7005, Vol. 30, no 12, 5227-5231 p.Article in journal (Refereed) Published
Aim: The aim of this study was to assess how age is related to differences in stage, tumour differentiation and treatment in colorectal cancer. Patients and Methods: A retrospective study in a consecutive series of colorectal cancer patients (n=2220) where age was related to demography, stage, tumour characteristics, treatment and outcome (OS/CSS) both as a continuous variable and grouped by high/low 10th percentiles, as young/old groups, with a third median reference group. Results: Young patients had more advanced cancer stages (p=0.012), higher N-status (p=0.011) and more frequent T4/G4 tumours. Old patients had higher postoperative mortality and were less likely to receive chemotherapy. The proportion of cancer-related deaths was stage-dependent and decreased with age. Conclusion: Cancer stage, tumour characteristics, treatment and outcome can vary with age in colorectal cancer. The increasing proportion of non-cancer deaths at a higher age can affect the use of overall survival as an outcome parameter, which may be of importance in evaluating clinical and translational research.
Place, publisher, year, edition, pages
International Institute of Anticancer Research , 2010. Vol. 30, no 12, 5227-5231 p.
Prognosis, cancer-specific survival, tumour characteristics
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-66327ISI: 000287018100065OAI: oai:DiVA.org:liu-66327DiVA: diva2:403207