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A New Optical Method for Measuring Creatinine Concentration Removed During Dialysis
(Tallinn University)
Tallinn University.
Tallinn University.
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
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2010 (English)In: XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 IFMBE Proceedings, 2010, Springer , 2010, 379-382 p.Conference paper (Refereed)
Abstract [en]

The aim of this study was to compare creatinine (Cr) concentration measurements removed during dialysis by two optical algorithms based on single wavelength and multiwavelength UV-absorbance. Ten uremic patients, three females and seven males, mean age 62.6 ± 18.6 years, on chronic thrice-weekly hemodialysis were included in the study. Double-beam spectrophotometer (Shimatsu UV-2401 PC, Japan) was used for the determination of UV-absorbance in the collected spent dialysate samples. Two optical algorithms were developed to calculate Cr concentration removed during dialysis from measured UVabsorbance: (i) an algorithm utilizing only a single wavelength, revealing Cr concentration Cr_sw; (ii) an algorithm utilizing several wavelengths (multiwavelength algorithm), revealing Cr concentration Cr_mw. The mean value of Cr estimated at the laboratory was 107 ± 46,7 micromol/l, while UV-absorbance as Cr_sw (242 nm) was 107 ± 42.7 micromol/l, and 107 ± 44.7 micromol/l as Cr_mw. The mean concentrations were not significantly different (P = 0.99). The systematic errors, using Cr_lab as a reference, were -2.7% for Cr_sw and -1.7% for Cr_mw, and random errors were 17.3% and 13.6% for Cr_sw and Cr_mw, respectively. The systematic error was not significantly different for two optical algorithms (P = 0.25). The random error decreased significantly (P < 0.05) using Cr_mw algorithm compared to the Cr_sw model. In summary, the creatinine concentration removed during dialysis can be estimated with UV-absorbance technique.

Place, publisher, year, edition, pages
Springer , 2010. 379-382 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-66401DOI: 10.1007/978-3-642-13039-7_95ISBN: 978-3-642-13038-0 (print)ISBN: 978-3-642-13039-7 (online)OAI: diva2:403717
Biomedical Engineering (BME) Conference, 2010, 27-30 May in Porto Carras, Chalkidiki, Greece
Available from: 2011-03-14 Created: 2011-03-14 Last updated: 2014-09-25

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Uhlin, Fredrik
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Internal MedicineFaculty of Health SciencesDepartment of Nephrology
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