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Postoperative intra-arterial methylene blue injection of colorectal cancer specimens increases the number of lymph nodes recovered
Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics. Linköping University, Faculty of Health Sciences.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland. Linköping University, Faculty of Health Sciences.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland. Linköping University, Faculty of Health Sciences.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland. Linköping University, Faculty of Health Sciences.
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2011 (English)In: HISTOPATHOLOGY, ISSN 0309-0167, Vol. 58, no 3, 408-413 p.Article in journal (Refereed) Published
Abstract [en]

Aims: To determine the possible advantage of intra-arterial injection of methylene blue with a view to improving lymph node recovery in postoperative examination of colorectal cancer specimens. Methods and results: Thirty-two colorectal cancer specimens were assigned randomly to either dissection with intra-arterial methylene blue injection or to routine dissection (without methylene blue injection). Immediately postoperatively, the specimens in the staining group were injected intra-arterially with methylene blue dye. The two procedures were compared with respect to the number of lymph nodes recovered. The number of recovered lymph nodes was significantly higher in the intra-arterial methylene blue injection group than in the group investigated with routine procedures (P andlt; 0.0001). Conclusion: The intra-arterial methylene blue injection method is fairly easy to use postoperatively and increases significantly the number of lymph nodes recovered in colorectal cancer specimens.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2011. Vol. 58, no 3, 408-413 p.
Keyword [en]
colorectal cancer, lymph nodes, methylene blue injection
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-66884DOI: 10.1111/j.1365-2559.2011.03755.xISI: 000287813200008OAI: oai:DiVA.org:liu-66884DiVA: diva2:405257
Available from: 2011-03-21 Created: 2011-03-21 Last updated: 2011-04-27Bibliographically approved

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Olsson, Hans

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Department of Clinical Pathology and Clinical GeneticsFaculty of Health SciencesDepartment of Surgery in ÖstergötlandMolecular and Immunological Pathology
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