Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding
2010 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 10, 2655-2658 p.Article in journal (Refereed) Published
Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.
Place, publisher, year, edition, pages
2010. Vol. 10, 2655-2658 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-66929DOI: 10.1039/C0LC00068JOAI: oai:DiVA.org:liu-66929DiVA: diva2:405384