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Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
Department of Physiology and Pharmacology, Karolinska Institutet.
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Department of Physiology and Pharmacology, Karolinska Institutet.
Department of Medical Sciences, Clinical Pharmacology, Uppsala University.
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2012 (English)In: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 38, no 3, 426-432 p.Article in journal (Refereed) Published
Abstract [en]

Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and alpha7* nicotinic receptors. Methods: The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA and its precursors, kynurenine (KYN) and TRP, in the cerebrospinal fluid (CSF) of patients with schizophrenia. CSF from male patients with schizophrenia on olanzapine treatment (n = 16) was compared with healthy male volunteers (n = 29). Results: KYN and KYNA concentrations were higher in patients with schizophrenia (60.7 +/- 4.37nM and 2.03 +/- 0.23nM, respectively) compared with healthy volunteers (28.6 +/- 1.44nM and 1.36 +/- 0.08nM, respectively), whereas TRP did not differ between the groups. In all subjects, KYN positively correlated to KYNA. Conclusion: Our results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.

Place, publisher, year, edition, pages
Oxford University Press, 2012. Vol. 38, no 3, 426-432 p.
Keyword [en]
psychosis, kynurenate, olanzapine, cerebrospinal fluid, tryptophan
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-66972DOI: 10.1093/schbul/sbq086ISI: 000303169000011PubMedID: 20729465OAI: oai:DiVA.org:liu-66972DiVA: diva2:405771
Available from: 2011-03-23 Created: 2011-03-23 Last updated: 2017-12-11

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Skogh, ElisabethSamuelsson, Martin

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