Sensitivity to heat in MS patients: a factor strongly influencing symptomology - an explorative survey
2011 (English)In: BMC NEUROLOGY, ISSN 1471-2377, Vol. 11, no 27Article in journal (Refereed) Published
Background: Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized as correlating with the symptom of fatigue. The need to explore this association has been highlighted. The aim of this study was to investigate the occurrence of heat sensitivity and its relations to disease course, disability, common MS-related symptoms and ongoing immunosuppressive treatments among individuals 65 years of age or younger diagnosed with MS. Methods: A cross-sectional designed survey was undertaken. A questionnaire was sent to MS-patients with an Expanded Disability Status Score (EDSS) in the interval of 0-6.5 and who were between 20 and 65 years of age, living in an eastern region of Sweden (n = 334). Besides occurrence of heat sensitivity (Yes/No) and corresponding questions, the Fatigue Severity Scale (FSS), the MS-related symptom checklist and the Perceived Deficit Questionnaire (PDQ) were included. Data were analysed in relation to data level using Chi-square, Mann Whitney U-test, and Students t-test. Pearsons and Spearmans correlations were calculated. In the logistic regression analyses (enter) dichotomized MS-symptoms were used as dependent variables, and EDSS, disease-course, time since onset, heat-sensitivity, age and sex (female/male) were independent variables. In the linear regression analyses, enter, mean FSS and summarized PDQ were entered as dependent variables and EDSS, disease-course, time since onset, heat sensitivity, age and sex (female/male) were independent variables. Results: Of the responding patients (n = 256), 58% reported heat sensitivity. The regression analyses revealed heat sensitivity as a significant factor relating not only to fatigue (p andlt; 0.001), but also to several other common MS symptoms such as pain (p andlt; 0.001), concentration difficulties (p andlt; 0.001), and urination urgency (p = 0.009). Conclusions: Heat sensitivity in MS patients is a key symptom that is highly correlated with disabling symptoms such as fatigue, pain, concentration difficulty and urination urgency.
Place, publisher, year, edition, pages
BioMed Central , 2011. Vol. 11, no 27
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-67032DOI: 10.1186/1471-2377-11-27ISI: 000288330000001OAI: oai:DiVA.org:liu-67032DiVA: diva2:406279
Original Publication: Gullvi Flensner, Anna-Christina Ek, Olle Soderhamn and Anne-Marie Landtblom, Sensitivity to heat in MS patients: a factor strongly influencing symptomology - an explorative survey, 2011, BMC NEUROLOGY, (11), 27. http://dx.doi.org/10.1186/1471-2377-11-27 Licensee: BioMed Central http://www.biomedcentral.com/2011-03-252011-03-252012-04-03