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Managing localized prostate cancer by radical prostatectomy or watchful waiting: Cost analysis of a randomized trial (SPCG-4)
Orebro University Hospital.
Orebro University Hospital.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics.
Brigham and Womens Hospital.
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2011 (English)In: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, ISSN 0036-5599, Vol. 45, no 3, 177-183 p.Article in journal (Refereed) Published
Abstract [en]

Objective. The cost of radical prostatectomy (RP) compared to watchful waiting (WW) has never been estimated in a randomized trial. The goal of this study was to estimate long-term total costs per patient associated with RP and WW arising from inpatient and outpatient hospital care. Material and methods. This investigation used the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) trial, comparing RP to WW, and included data from 212 participants living in two counties in Sweden from 1989 to 1999 (105 randomized to WW and 107 to RP). All costs were included from randomization date until death or end of follow-up in July 2007. Resource use arising from inpatient and outpatient hospital costs was measured in physical units and multiplied by a unit cost to come up with a total cost per patient. Results. During a median follow-up of 12 years, the overall cost in the RP group was 34% higher (p andlt; 0.01) than in the WW group, corresponding to euroa,not sign6123 in Sweden. The difference was driven almost exclusively by the cost of the surgical procedure. The cost difference between RP and WW was two times higher among men with low (2--6) than among those with high (7--10) Gleason score. Conclusion. In this economic evaluation of RP versus WW of localized prostate cancer in a randomized study, RP was associated with 34% higher costs. This difference, attributed exclusively to the cost of the RP procedure, was not overcome during extended follow-up.

Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 45, no 3, 177-183 p.
Keyword [en]
Cost-effectiveness, prostate cancer, randomized trial, radical prostatectomy, watchful waiting
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-67149DOI: 10.3109/00365599.2010.545075ISI: 000288379800003OAI: diva2:407905
Available from: 2011-04-01 Created: 2011-04-01 Last updated: 2012-03-26

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Lyth, JohanHenriksson, MartinCarlsson, Per
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