Fluid-induced osteolysis: modelling and experiments
2011 (English)In: COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, ISSN 1025-5842, Vol. 14, no 4, 305-318 p.Article in journal (Refereed) Published
A model to calculate bone resorption driven by fluid flow at the bone-soft tissue interface is developed and used as a basis for computer calculations, which are compared to experiments where bone is subjected to fluid flow in a rat model. Previous models for bone remodelling calculations have been based on the state of stress, strain or energy density of the bone tissue as the stimulus for remodelling. We believe that there is experimental support for an additional pathway where an increase in the amount of the cells directly involved in bone removal, the osteoclasts, is caused by fluid pressure, flow velocity or other parameters related to fluid flow at the bone-soft tissue interface, resulting in bone resorption.
Place, publisher, year, edition, pages
Taylor and Francis , 2011. Vol. 14, no 4, 305-318 p.
bone resorption, theory of mixtures, experimental model, finite element method
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-67561DOI: 10.1080/10255842.2010.484808ISI: 000288951800001OAI: oai:DiVA.org:liu-67561DiVA: diva2:411243