Genistein ameliorates learning and memory deficits in amyloid beta((1-40)) rat model of Alzheimers disease
2011 (English)In: Neurobiology of Learning and Memory, ISSN 1074-7427, E-ISSN 1095-9564, Vol. 95, no 3, 270-276 p.Article in journal (Refereed) Published
Alzheimers disease (AD) is a debilitating neurodegenerative disorder characterized by increased beta-amyloid (A beta) deposition and neuronal dysfunction leading to impaired learning and recall. Ageing, heredity, and induced oxidative stress are among proposed risk factors. The increased frequency of the disease in women also suggests a role for estrogen in development of AD. In the present study, effects of the phytoestrogen genistein (10 mg/kg) on learning and memory impairments was assessed in intrahippocampal A beta((1-40))-injected rats. The estrogen receptor antagonist fulvestrant was injected intracerebroventricularly in a group of A beta-lesioned rats. The A beta-injected animals exhibited the following: lower spontaneous alternation score in Y-maze tasks, impaired retention and recall capability in the passive avoidance test, and fewer correct choices and more errors in the RAM task. Genistein, but not genistein and fulvestrant, significantly improved most of these parameters. Measurements of oxidative stress markers in hippocampal tissue of A beta-injected rats showed an elevation of malondialdehyde (MDA) and nitrite content, and a reduction of superoxide dismutase (SOD) activity. Genistein significantly attenuated the increased MDA content but did not affect the nitrite content or SOD activity. These results indicate that genistein pretreatment ameliorates A beta-induced impairment of short-term spatial memory in rats through an estrogenic pathway and by inducing attenuation of oxidative stress.
Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam , 2011. Vol. 95, no 3, 270-276 p.
Alzheimers disease, Beta-amyloid, Genistein, Learning and memory
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-67550DOI: 10.1016/j.nlm.2010.12.001ISI: 000288774300006OAI: oai:DiVA.org:liu-67550DiVA: diva2:411256
Original Publication: Maryam Bagheri, Mohammad-Taghi Joghataei, Simin Mohseni and Mehrdad Roghani, Genistein ameliorates learning and memory deficits in amyloid beta((1-40)) rat model of Alzheimers disease, 2011, NEUROBIOLOGY OF LEARNING AND MEMORY, (95), 3, 270-276. http://dx.doi.org/10.1016/j.nlm.2010.12.001 Copyright: Elsevier Science B.V., Amsterdam http://www.elsevier.com/2011-04-182011-04-182016-02-29Bibliographically approved