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Platelet function assessed by whole-blood aggregometry in patients undergoing non-cardiac surgery
Östergötlands Läns Landsting, Sinnescentrum, Department of Intensive Care UHL.
Östergötlands Läns Landsting, Sinnescentrum, Department of Intensive Care UHL.
Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Chemistry.
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2011 (English)In: EUROPEAN JOURNAL OF ANAESTHESIOLOGY, ISSN 0265-0215, Vol. 28, no 5, 363-369 p.Article in journal (Refereed) Published
Abstract [en]

Background The risk/benefit of continuing low-dose acetylsalicylic acid (aspirin) for secondary prevention in the perioperative period is still debated. The primary aim of this study was to determine the effect of acetylsalicylic acid compared with placebo on platelet function in the perioperative period. Methods This is a subgroup analysis of a randomised, double-blind, placebo-controlled multicentre study. High-risk patients undergoing major non-cardiac surgery were randomised to 75 mg acetylsalicylic acid or placebo 7 days preoperatively, until the third postoperative day. In 36 patients, platelet function in response to arachidonic acid was assessed by whole-blood impedance aggregometry using a multiplate analyser 1 h before surgery, directly after surgery and 48 h postoperatively. Results The platelet function was significantly reduced in patients treated with acetylsalicylic acid compared with placebo in the preoperative period [200 aggregation units (AU) min (interquartile range [IQR] 133-261 AU min(-1)) vs. 860 AU min (IQR 800-1010 AU min), P andlt; 0.001] as well as postoperatively [198 AU min (IQR 138-270 AU min) vs. 605 AU min (IQR 434-836 AU min), Pandlt;0.001]. The platelet response was significantly reduced postoperatively compared with preoperatively in patients receiving placebo [860 AU min (IQR 800-1010 AU min) vs. 605 AU min (IQR 434-861 AU min), P=0.0009]. No significant differences were found between pre- and postoperative platelet function in patients on acetylsalicylic acid [200 AU min (IQR 133-261 AU min) vs. 198 AU min (133-270 AU min), P=0.21]. Conclusion Multiplate whole-blood impedance aggregometry demonstrates acetylsalicylic affect in preoperative as well as postoperative samples derived from patients undergoing non-cardiac surgery.

Place, publisher, year, edition, pages
Cambridge University Press , 2011. Vol. 28, no 5, 363-369 p.
Keyword [en]
acetylsalicylic acid, aggregometry, non-cardiac, platelet function, surgery
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-67835DOI: 10.1097/EJA.0b013e32834448edISI: 000289459200012OAI: oai:DiVA.org:liu-67835DiVA: diva2:413593
Available from: 2011-04-29 Created: 2011-04-29 Last updated: 2012-03-20

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Fredrikson, MatsLindahl, TomasEintrei, Christina

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Department of Intensive Care UHLOccupational and Environmental MedicineFaculty of Health SciencesClinical ChemistryDepartment of Clinical ChemistryAnesthesiology
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