liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Drug therapy of cancer
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
2011 (English)In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, ISSN 0031-6970, Vol. 67, no 5, 437-447 p.Article, review/survey (Refereed) Published
Abstract [en]

Cancer chemotherapy was introduced at the same time as antibacterial chemotherapy but has not been nearly such a success. However, there is a growing optimism in oncology today due to the introduction of several more or less target-specific drugs as complements to the conventional cytotoxic drugs introduced half a century ago. The success in the treatment of chronic myelogenous leukemia by imatinib, inhibiting the bcrabl-activated tyrosine kinase and thereby interrupting the signal transduction pathways that lead to leukemic transformation with impressive survival benefit, has paved the way for this new optimism. Another success story is the introduction of trastuzumab in breast cancers overexpressing the HER-2 receptor. In contrast, there has been little progress in other malignancies such as metastatic malignant melanoma, although very recently, clinical trials with new targeted drugs have shown increased survival. All major pharmaceutical companies now have ambitious development programs in the cancer area. However, the high costs of the novel drugs cause economic distress in the health care system in many countries leading to an intense debate on the cost-effectiveness of these drugs in relation to other health care activities.

Place, publisher, year, edition, pages
Springer Science Business Media , 2011. Vol. 67, no 5, 437-447 p.
Keyword [en]
Cancer treatment, Cytotoxic drugs, Targeted drugs, Tyrosine kinase inhibitors, Monoclonal antibodies
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-67971DOI: 10.1007/s00228-011-1011-xISI: 000289524400002OAI: diva2:414730
Available from: 2011-05-04 Created: 2011-05-04 Last updated: 2011-05-04

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Peterson, Curt
By organisation
Clinical PharmacologyFaculty of Health SciencesDepartment of Oncology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 34 hits
ReferencesLink to record
Permanent link

Direct link