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Relation between bone mineral density, biological markers and anthropometric measures in 4-year-old children: a pilot study within the IDEFICS study
University of Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Chemistry.
University of Gothenburg.
University of Gothenburg.
2011 (English)In: INTERNATIONAL JOURNAL OF OBESITY, ISSN 0307-0565, Vol. 35, S119-S124 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the relationship between bone mineral density (BMD), anthropometric characteristics, levels of biological markers for growth, bone turnover, insulin resistance and fat mass in 4-year-old Swedish children. Methods: Descriptive study with 41 children (28 boys) who had anthropometric measurements and blood samples taken and heel dual-energy X-ray absorptiometry and laser (DXL) performed. The study participants were divided into groups of normal-weight (n = 28) and overweight or obese (n = 13) children. Results: There was a significant difference in bone mineral content (BMC), BMD and bone mineral apparent density (BMAD) between overweight and normal-weight children. There was a significant positive correlation between BMC, BMD, BMAD and body mass index standard deviation scores (r = 0.36, 0.34 and 0.29, P andlt; 0.01, respectively), waist circumference (r = 0.32, 0.30, P andlt; 0.01 and r = 0.26, P andlt; 0.05, respectively) and subscapular skinfold (r = 0.26, 0.25 and 0.23, P andlt; 0.05, respectively). BMC and BMD correlated significantly with the sum of skinfold measures (r = 0.25 and 0.23, P andlt; 0.05, respectively). Adiponectin was significantly inversely correlated with BMC, BMD and BMAD (r = -0.41, -0.40 and -0.41, P andlt; 0.01, respectively). Adiponectin was not correlated with skinfold measures. Multiple regression analysis revealed that adiponectin was an independent determinant of BMD, BMC and BMAD. Conclusion: To our knowledge, this is the first study investigating BMD assessed by heel-DXL in relation to anthropometry and metabolic markers in 4-year-old children. Adiponectin was significantly inversely correlated with bone mass parameters. Adiponectin may have an independent role in bone development and metabolism in young children.

Place, publisher, year, edition, pages
Nature Publishing Group , 2011. Vol. 35, S119-S124 p.
Keyword [en]
bone, DXL, leptin, adiponectin, paediatric, osteocalcin
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-67969DOI: 10.1038/ijo.2011.42ISI: 000289515100015OAI: diva2:414732
Available from: 2011-05-04 Created: 2011-05-04 Last updated: 2012-02-14

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Magnusson, Per
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Clinical ChemistryFaculty of Health SciencesDepartment of Clinical Chemistry
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