Cytotoxic mechanisms may play a role in the local immune response in the central nervous system in neuroborreliosis
2011 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 232, no 1-2, 186-193 p.Article in journal (Refereed) Published
Aiming to investigate the role of cytotoxic mechanisms in neuroborreliosis (NB), the cytokines IL-2, IL-7, IL-10, IL-12p70, IL-15, GM-CSF and the Th17-cytokine IL-17 were analyzed in cerebrospinal fluid (CSF) and plasma from NB-patients. NB-patients showed increased levels in CSF compared to controls of all analyzed cytokines except IL-15 but not in plasma. Blood lymphocytes from three NB-patients showed functional cytotoxicity in response to autologous Borrelia-infected macrophages. The findings support a role for cytotoxic mechanisms in the local immune response in NB and in addition suggest an increase of IL-17.
Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2011. Vol. 232, no 1-2, 186-193 p.
Cytotoxic mechanisms, Neuroborreliosis, IL-17, Lyme borreliosis, Persisting symptoms
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-67968DOI: 10.1016/j.jneuroim.2010.09.028ISI: 000289493700025OAI: oai:DiVA.org:liu-67968DiVA: diva2:414733