liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice
University of Waikato.
University of Waikato.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology.
University of Waikato.
Show others and affiliations
2011 (English)In: ANAESTHESIA, ISSN 0003-2409, Vol. 66, no 5, 361-367 p.Article in journal (Refereed) Published
Abstract [en]

Pandgt;Gap junction blockade is a possible mechanism by which general anaesthetic drugs cause unconsciousness. We measured the sensitivity of connexin36 knockout mice to the hypnotic effects of isoflurane and propofol. The experimental endpoint was recovery of the righting reflex of the anaesthetised animals during 0.2% step-reductions in isoflurane concentration, or following intraperitoneal injection of propofol (100 mg.kg-1). Connexin36 knockout animals were more sensitive to the hypnotic effects of isoflurane than normal wild-type animals. The half maximal effective concentration (EC50) for recovery of righting reflex was 0.37% for connexin36 knockout vs 0.49% for wild-type animals (p andlt; 0.001). For propofol, connnexin36 knockout animals showed more rapid loss of righting reflex than wild-type animals (mean (SD) 2.8 (0.13) vs 3.8 (0.27) min); and young (andlt; 60 days) connexin36 knockout animals remained anaesthetised for longer than young wild-type mice (47.2 (2.9) vs 30.5 (1.7) min; p andlt; 0.00001). These findings suggest that the hypnotic effects of anaesthetic drugs may be moderately enhanced by gap junction blockade.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2011. Vol. 66, no 5, 361-367 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-68184DOI: 10.1111/j.1365-2044.2011.06658.xISI: 000289365300007OAI: oai:DiVA.org:liu-68184DiVA: diva2:416829
Available from: 2011-05-13 Created: 2011-05-13 Last updated: 2012-03-25

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Melin, Sara

Search in DiVA

By author/editor
Melin, Sara
By organisation
Faculty of Health SciencesMedical Microbiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf