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The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice
University of Waikato.
University of Waikato.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology.
University of Waikato.
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2011 (English)In: ANAESTHESIA, ISSN 0003-2409, Vol. 66, no 5, 361-367 p.Article in journal (Refereed) Published
Abstract [en]

Pandgt;Gap junction blockade is a possible mechanism by which general anaesthetic drugs cause unconsciousness. We measured the sensitivity of connexin36 knockout mice to the hypnotic effects of isoflurane and propofol. The experimental endpoint was recovery of the righting reflex of the anaesthetised animals during 0.2% step-reductions in isoflurane concentration, or following intraperitoneal injection of propofol (100 Connexin36 knockout animals were more sensitive to the hypnotic effects of isoflurane than normal wild-type animals. The half maximal effective concentration (EC50) for recovery of righting reflex was 0.37% for connexin36 knockout vs 0.49% for wild-type animals (p andlt; 0.001). For propofol, connnexin36 knockout animals showed more rapid loss of righting reflex than wild-type animals (mean (SD) 2.8 (0.13) vs 3.8 (0.27) min); and young (andlt; 60 days) connexin36 knockout animals remained anaesthetised for longer than young wild-type mice (47.2 (2.9) vs 30.5 (1.7) min; p andlt; 0.00001). These findings suggest that the hypnotic effects of anaesthetic drugs may be moderately enhanced by gap junction blockade.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2011. Vol. 66, no 5, 361-367 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-68184DOI: 10.1111/j.1365-2044.2011.06658.xISI: 000289365300007OAI: diva2:416829
Available from: 2011-05-13 Created: 2011-05-13 Last updated: 2012-03-25

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Melin, Sara
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