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Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer
University Uppsala Hospital.
University Uppsala Hospital.
University of Helsinki.
University Uppsala Hospital.
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2011 (English)In: NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, Vol. 364, no 18, 1708-1717 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND In 2008, we reported that radical prostatectomy, as compared with watchful waiting, reduces the rate of death from prostate cancer. After an additional 3 years of follow-up, we now report estimated 15-year results. METHODS From October 1989 through February 1999, we randomly assigned 695 men with early prostate cancer to watchful waiting or radical prostatectomy. Follow-up was complete through December 2009, with histopathological review of biopsy and radical-prostatectomy specimens and blinded evaluation of causes of death. Relative risks, with 95% confidence intervals, were estimated with the use of a Cox proportional-hazards model. RESULTS During a median of 12.8 years, 166 of the 347 men in the radical-prostatectomy group and 201 of the 348 in the watchful-waiting group died (P=0.007). In the case of 55 men assigned to surgery and 81 men assigned to watchful waiting, death was due to prostate cancer. This yielded a cumulative incidence of death from prostate cancer at 15 years of 14.6% and 20.7%, respectively (a difference of 6.1 percentage points; 95% confidence interval [CI], 0.2 to 12.0), and a relative risk with surgery of 0.62 (95% CI, 0.44 to 0.87; P=0.01). The survival benefit was similar before and after 9 years of follow-up, was observed also among men with low-risk prostate cancer, and was confined to men younger than 65 years of age. The number needed to treat to avert one death was 15 overall and 7 for men younger than 65 years of age. Among men who underwent radical prostatectomy, those with extracapsular tumor growth had a risk of death from prostate cancer that was 7 times that of men without extracapsular tumor growth (relative risk, 6.9; 95% CI, 2.6 to 18.4). CONCLUSIONS Radical prostatectomy was associated with a reduction in the rate of death from prostate cancer. Men with extracapsular tumor growth may benefit from adjuvant local or systemic treatment.

Place, publisher, year, edition, pages
Massachusetts Medical Society , 2011. Vol. 364, no 18, 1708-1717 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-68215DOI: 10.1056/NEJMoa1011967ISI: 000290219800007OAI: oai:DiVA.org:liu-68215DiVA: diva2:416877
Available from: 2011-05-13 Created: 2011-05-13 Last updated: 2011-05-13

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Spångberg, Anders

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UrologyFaculty of Health SciencesDepartment of Urology in Östergötland
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