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Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue
Department of Physics, Lund University.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0555-8877
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
Department of Physics, Lund University.
2011 (English)In: IEEE Photonics Journal, ISSN 1943-0655, Vol. 3, no 3, 407-421 p.Article in journal (Other academic) Published
Abstract [en]

In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers , 2011. Vol. 3, no 3, 407-421 p.
Keyword [en]
Fluorescence-guided resection, FGR, 5-ALA, PpIX, protoporphyrin, photobleaching, laser-induced fluorescence spectroscopy, LIF, optical diagnostics, tissue optics, skin, brain, dynamic models, system identification, state space models.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-68345DOI: 10.1109/JPHOT.2011.2141656ISI: 000290429400001OAI: oai:DiVA.org:liu-68345DiVA: diva2:418142
Available from: 2011-05-20 Created: 2011-05-20 Last updated: 2017-02-09Bibliographically approved

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Haj-Hosseini, NedaWårdell, Karin

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