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Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology . Linköping University, The Institute of Technology.
Cellartis AB, Gothenburg, Sweden.
Biochemical Engineering, Saarland University, Saarbruecken, Germany.
MultiChannel Systems GmbH, Reutlingen, Germany.
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2011 (English)In: JOURNAL OF APPLIED TOXICOLOGY, ISSN 0260-437X, Vol. 31, no 3, 191-205 p.Article, review/survey (Refereed) Published
Abstract [en]

In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art bioanalytical methods and sensors is reviewed. The focus is on hESC-derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring critical cardiotoxicity parameters are highlighted, together with aspects of data evaluation and validation. Finally, recommendations for further research are given.

Place, publisher, year, edition, pages
John Wiley and Sons, Ltd , 2011. Vol. 31, no 3, 191-205 p.
Keyword [en]
human embryonic stem cells, in vitro toxicity, cardiomyocyte, cardiotoxicity, cytotoxicity, electrophysiology, multielectrode array, surface plasmon resonance, respiration, metabolomics
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-68689DOI: 10.1002/jat.1663ISI: 000290290800001OAI: diva2:419711
Available from: 2011-05-27 Created: 2011-05-27 Last updated: 2011-05-30

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Mandenius, Carl-Fredrik
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