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Cationic polymer brush grafted-nanodiamond via atom transfer radical polymerization for enhanced gene delivery and bioimaging
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, China.
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, China.
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, China.
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, China.
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2011 (English)In: JOURNAL OF MATERIALS CHEMISTRY, ISSN 0959-9428, Vol. 21, no 21, 7755-7764 p.Article in journal (Refereed) Published
Abstract [en]

A novel cationic nanodiamond-polymer brush was synthesized by 2-bromoisobutyrate-modified nanodiamond (ND) surface-initiated atomic transfer radical polymerization of 2-(dimethylamino)ethyl methacrylate (DMAEMA). Elemental analysis, FTIR, HRTEM, TGA and zeta potential analysis were used to confirm the successful synthesis of ND-polymer brushes. It was shown that the ND-brushes were capable of condensing plasmid DNA into stable nanoparticles, protecting DNA from enzyme degradation. Transfection studies demonstrated that the ND-brushes could not only efficiently deliver plasmids into COS-7 cells, but also mediate higher expression than PEI25k with lower cytotoxicity. The green fluorescence of ND-brushes could also be detected by laser scanning confocal microscopy, making the nanodiamond-polymer brushes an excellent multifunctional gene vector with not only high transfection efficiency but allowing for bioimaging.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2011. Vol. 21, no 21, 7755-7764 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-68787DOI: 10.1039/c1jm10813aISI: 000290670000033OAI: oai:DiVA.org:liu-68787DiVA: diva2:420868
Available from: 2011-06-07 Created: 2011-06-07 Last updated: 2013-12-17

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Griffith, May

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