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Is there an increased risk for drug treated attention deficit/hyperactivity disorder in children born after in vitro fertilization?
Tornblad Institute, University of Lund.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Stockholm.
Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Stockholm.
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2011 (English)In: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, ISSN 1090-3798, Vol. 15, no 3, 247-253 p.Article in journal (Refereed) Published
Abstract [en]

Background: There is mounting evidence that children born after in vitro fertilization (IVF) run an increased risk of neurological complications and notably cerebral palsy. Whether developmental disturbances occur more often than expected is debated. Aim: To investigate the risk for ADHD in children conceived after IVF. Methods: Children conceived after IVF and born between 1982 and 2005 were identified from all IVF clinics in Sweden. Children who developed attention deficit/hyperactivity disorder (ADHD) were identified with the use of a register over all prescribed drugs in Sweden, using prescriptions for methylphenidate or atomixetine as indicators of ADHD. Maternal and neonatal characteristics were obtained by linkage with the Medical Birth Register and relevant confounders were adjusted for using Mantel-Haenszel procedures. We studied 28158 children born after IVF and compared them with 2417886 children in the population. Results: After adjustment for year of birth, maternal age, parity, smoking, BMI, and maternal education and after exclusion of women who did not cohabit, a weak but statistically significant association was found with an odds ratio = 1.18, 95% confidence interval 1.03-1.36. The effect was stronger in girls (OR = 1.40) than boys (OR = 1.11) but this difference could be random. After adjustment for length of involuntary childlessness, the OR decreased slightly and lost statistical significance. Conclusions: The study suggests a weak association between IVF and drug treated ADHD.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam , 2011. Vol. 15, no 3, 247-253 p.
Keyword [en]
Attention deficit/hyperactivity disorder, Confounding, Epidemiology, In vitro fertilization
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-68822DOI: 10.1016/j.ejpn.2010.12.004ISI: 000290842100010OAI: diva2:421228
Available from: 2011-06-08 Created: 2011-06-08 Last updated: 2011-06-13

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Finnström, Orvar
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PediatricsFaculty of Health SciencesDepartment of Paediatrics in Linköping
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